In mitochondria, most Coenzyme Q is free in the lipid bilayer; the question as to whether tightly-bound, non-exchangeable Coenzyme Q molecules exist in mitochondrial complexes is still an open question. We review the mechanism of inter-complex electron transfer mediated by ubiquinone and discuss the kinetic consequences of the supramolecolar organization of the respiratory complexes (randomly dispersed vs. super-complexes) in terms of Coenzyme Q pool behavior vs.metabolic channeling, respectively, both in physiological and in some pathological conditions. As an example of intra-complex electron transfer, we discuss in particular Complex I, a topic that is still under active investigation.
Lenaz G., Fato R., Formiggini G., Genova ML. (2007). The role of Coenzyme Q in mitochondrial electron transport. MITOCHONDRION, 7S, S8-S33 [10.1016/j.mito.2007.03.009].
The role of Coenzyme Q in mitochondrial electron transport
LENAZ, GIORGIO;FATO, ROMANA;FORMIGGINI, GABRIELLA;GENOVA, MARIA LUISA
2007
Abstract
In mitochondria, most Coenzyme Q is free in the lipid bilayer; the question as to whether tightly-bound, non-exchangeable Coenzyme Q molecules exist in mitochondrial complexes is still an open question. We review the mechanism of inter-complex electron transfer mediated by ubiquinone and discuss the kinetic consequences of the supramolecolar organization of the respiratory complexes (randomly dispersed vs. super-complexes) in terms of Coenzyme Q pool behavior vs.metabolic channeling, respectively, both in physiological and in some pathological conditions. As an example of intra-complex electron transfer, we discuss in particular Complex I, a topic that is still under active investigation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
