In different species, REM sleep (REMS) occurrence appears to be finely regulated on either a short (Vivaldi E, 1994) or a long-term basis (Parmeggiani PL, 1980). However, the hypothesis that REMS amount is homeostatically regulated is challenged by data on humans which show that a scarce REMS rebound follows REMS deprivation (Horne J, 2000). Further analysis was carried out on data from an experiment in which 24 male Sprague-Dawley rats (250g) were exposed for 24h to different low ambient temperatures (Tas, ranging from –10°C to 10°C) and then allowed to recover for 4 days at normal laboratory Ta (Cerri M, 2005). REMS decreased proportionally with cold exposure, but a quick compensatory REMS rebound occurred during the first day of recovery when the previous loss went beyond an “alarm” threshold (AT) corresponding to 22% of the REMS daily need. By using data from literature we have calculated that AT for cats (Parmeggiani PL, 1980) and humans (Endo T, 1998) should correspond to 72% and 234% of the REMS daily need. Examining the three species together, AT appears to increase proportionally to the average duration of the REMS episode. It also appears to be positively related to their brain mass (Kg) according to a power function: y = 226.03x 0.36 , r2=0.986. This would suggest that, in analogy to what has been observed regarding the body’s energy needs, small mammals have a smaller capacity to buffer their REMS need than large ones.
REM sleep homeostasis: a matter of size? / Amici R.; Baracchi F.; Cerri M.; Del Sindaco E.; Jones C.A.; Luppi M.; Martelli D.; Perez E.; Zamboni G.. - In: SLEEP AND BIOLOGICAL RHYTHMS. - ISSN 1446-9235. - STAMPA. - 5 (suppl.1):(2007), pp. A86-A86. (Intervento presentato al convegno 5th World Congress of the WFSRSMS tenutosi a Cairns, Australia nel 2-6 september 2007).
REM sleep homeostasis: a matter of size?
AMICI, ROBERTO;BARACCHI, FRANCESCA;CERRI, MATTEO;DEL SINDACO, ELIDE;JONES, CHRISTINE ANN;LUPPI, MARCO;MARTELLI, DAVIDE;PEREZ, EMANUELE;ZAMBONI GRUPPIONI, GIOVANNI
2007
Abstract
In different species, REM sleep (REMS) occurrence appears to be finely regulated on either a short (Vivaldi E, 1994) or a long-term basis (Parmeggiani PL, 1980). However, the hypothesis that REMS amount is homeostatically regulated is challenged by data on humans which show that a scarce REMS rebound follows REMS deprivation (Horne J, 2000). Further analysis was carried out on data from an experiment in which 24 male Sprague-Dawley rats (250g) were exposed for 24h to different low ambient temperatures (Tas, ranging from –10°C to 10°C) and then allowed to recover for 4 days at normal laboratory Ta (Cerri M, 2005). REMS decreased proportionally with cold exposure, but a quick compensatory REMS rebound occurred during the first day of recovery when the previous loss went beyond an “alarm” threshold (AT) corresponding to 22% of the REMS daily need. By using data from literature we have calculated that AT for cats (Parmeggiani PL, 1980) and humans (Endo T, 1998) should correspond to 72% and 234% of the REMS daily need. Examining the three species together, AT appears to increase proportionally to the average duration of the REMS episode. It also appears to be positively related to their brain mass (Kg) according to a power function: y = 226.03x 0.36 , r2=0.986. This would suggest that, in analogy to what has been observed regarding the body’s energy needs, small mammals have a smaller capacity to buffer their REMS need than large ones.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
