The first direct asymmetric hydrophosphination (AHP) of nitroalkenes has been accomplished. The use of bifunctional cinchona alkaloid catalyst has provided an useful organocatalytic route to optically active β-nitro phosphines (up to 99% ee after crystallization). This organocatalytic AHP approach, providing a direct route to a new class of potentially useful enantiopure P,N-ligands, constitutes a bridge between the two complementary areas of asymmetric catalysis: organo- and metal-catalysed transformations.
Organocatalytic asymmetric hydrophosphination of nitroalkenes / G. Bartoli; M. Bosco; A. Carlone; M. Locatelli; A. Mazzanti; L. Sambri; P. Melchiorre. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 2007:(2007), pp. 722-724. [10.1039/b613477g]
Organocatalytic asymmetric hydrophosphination of nitroalkenes
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;CARLONE, ARMANDO;LOCATELLI, MANUELA;MAZZANTI, ANDREA;SAMBRI, LETIZIA;MELCHIORRE, PAOLO
2007
Abstract
The first direct asymmetric hydrophosphination (AHP) of nitroalkenes has been accomplished. The use of bifunctional cinchona alkaloid catalyst has provided an useful organocatalytic route to optically active β-nitro phosphines (up to 99% ee after crystallization). This organocatalytic AHP approach, providing a direct route to a new class of potentially useful enantiopure P,N-ligands, constitutes a bridge between the two complementary areas of asymmetric catalysis: organo- and metal-catalysed transformations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
