The first direct asymmetric hydrophosphination (AHP) of nitroalkenes has been accomplished. The use of bifunctional cinchona alkaloid catalyst has provided an useful organocatalytic route to optically active β-nitro phosphines (up to 99% ee after crystallization). This organocatalytic AHP approach, providing a direct route to a new class of potentially useful enantiopure P,N-ligands, constitutes a bridge between the two complementary areas of asymmetric catalysis: organo- and metal-catalysed transformations.
Organocatalytic asymmetric hydrophosphination of nitroalkenes
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;CARLONE, ARMANDO;LOCATELLI, MANUELA;MAZZANTI, ANDREA;SAMBRI, LETIZIA;MELCHIORRE, PAOLO
2007
Abstract
The first direct asymmetric hydrophosphination (AHP) of nitroalkenes has been accomplished. The use of bifunctional cinchona alkaloid catalyst has provided an useful organocatalytic route to optically active β-nitro phosphines (up to 99% ee after crystallization). This organocatalytic AHP approach, providing a direct route to a new class of potentially useful enantiopure P,N-ligands, constitutes a bridge between the two complementary areas of asymmetric catalysis: organo- and metal-catalysed transformations.File in questo prodotto:
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