The first general and highly enantioselective organocatalytic Friedel-Crafts alkylation of indoles with simple unsaturated ketones has been accomplished. Central to these studies has been the identification of a new catalyst amine salt, in which both the cation and the anion are chiral, that exhibits high reactivity and selectivity for iminium ion catalysis.
G. Bartoli, M. Bosco, A. Carlone, F. Pesciaioli, L. Sambri, P. Melchiorre (2007). Organocatalytic Asymmetric Friedel-Crafts Alkylation of Indoles with Simple α,β-Unsaturated Ketones. ORGANIC LETTERS, 9, 1403-1405 [10.1021/ol070309o].
Organocatalytic Asymmetric Friedel-Crafts Alkylation of Indoles with Simple α,β-Unsaturated Ketones
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;CARLONE, ARMANDO;PESCIAIOLI, FABIO;SAMBRI, LETIZIA;MELCHIORRE, PAOLO
2007
Abstract
The first general and highly enantioselective organocatalytic Friedel-Crafts alkylation of indoles with simple unsaturated ketones has been accomplished. Central to these studies has been the identification of a new catalyst amine salt, in which both the cation and the anion are chiral, that exhibits high reactivity and selectivity for iminium ion catalysis.File in questo prodotto:
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