The first general and highly enantioselective organocatalytic Friedel-Crafts alkylation of indoles with simple unsaturated ketones has been accomplished. Central to these studies has been the identification of a new catalyst amine salt, in which both the cation and the anion are chiral, that exhibits high reactivity and selectivity for iminium ion catalysis.
Organocatalytic Asymmetric Friedel-Crafts Alkylation of Indoles with Simple α,β-Unsaturated Ketones
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;CARLONE, ARMANDO;PESCIAIOLI, FABIO;SAMBRI, LETIZIA;MELCHIORRE, PAOLO
2007
Abstract
The first general and highly enantioselective organocatalytic Friedel-Crafts alkylation of indoles with simple unsaturated ketones has been accomplished. Central to these studies has been the identification of a new catalyst amine salt, in which both the cation and the anion are chiral, that exhibits high reactivity and selectivity for iminium ion catalysis.File in questo prodotto:
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