Gamma-Hydroxybutyric acid is a shortchain fatty acid structurally similar to the inhibitory neurotransmitter +-aminobutyric acid that exerts an ethanol-mimicking effect on the central nervous system by acting on its own receptor and the GABAB receptor. It has been extensively documented that this activation enhances dopamine release, with a consequent behavioral reinforcing effect. This knowledge has stimulated the accomplishment of preclinical and clinical studies, which helped to establish the indications for the use of this drug.
Caputo F, Vignoli T, Francini S, Stoppo M, Bernardi M. (2007). GABAergic medications for treating alcohol dependence. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 27, 539-540 [10.1097/JCP.0b013e31814fb51a].
GABAergic medications for treating alcohol dependence.
CAPUTO, FABIO;VIGNOLI, TEO;BERNARDI, MAURO
2007
Abstract
Gamma-Hydroxybutyric acid is a shortchain fatty acid structurally similar to the inhibitory neurotransmitter +-aminobutyric acid that exerts an ethanol-mimicking effect on the central nervous system by acting on its own receptor and the GABAB receptor. It has been extensively documented that this activation enhances dopamine release, with a consequent behavioral reinforcing effect. This knowledge has stimulated the accomplishment of preclinical and clinical studies, which helped to establish the indications for the use of this drug.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
