Several studies suggest the employment of retinoids in the therapy of cancer. These molecules, that are natural derivatives of vitamin A or retinol and include the all-trans-retinoic acid (RA), play important roles in modulating normal or tumor cell growth through the regulation of differentiation and/or apoptosis. The clinical use of retinoids is complicated by the fact that the doses needed for successful treatment are often toxic, leading to hypervitaminosis A syndrome; another major problem is that in some patients cancer cells become resistant to these compounds. The retinoid signal is mediated in target cells through specific nuclear receptors: the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RARs and RXRs are divergent in their ligand specificity; RA can bind and activate only RAR receptors, by contrast, 9-cis- retinoic acid binds RARs and RXRs, but with different affinities. It has been demonstrated that the retinoids that are ligands of RXR are ef
G.Bartolini, A.Papi, K.Ammar, A.M.Ferreri, P.Rocchi, M.Orlandi (2007). ANTITUMORAL EFFECT OF RETINOIDS: A COMPARISON BETWEEN ALL TRANS RETINOIC ACID AND IIF, A SPECIFIC LIGAND OF RXR. NEW YORK : Nova Science Publishers.
ANTITUMORAL EFFECT OF RETINOIDS: A COMPARISON BETWEEN ALL TRANS RETINOIC ACID AND IIF, A SPECIFIC LIGAND OF RXR
BARTOLINI, GIOVANNA;PAPI, ALESSIO;FERRERI, ANNA MARIA;ROCCHI, PAOLA;ORLANDI, MARINA
2007
Abstract
Several studies suggest the employment of retinoids in the therapy of cancer. These molecules, that are natural derivatives of vitamin A or retinol and include the all-trans-retinoic acid (RA), play important roles in modulating normal or tumor cell growth through the regulation of differentiation and/or apoptosis. The clinical use of retinoids is complicated by the fact that the doses needed for successful treatment are often toxic, leading to hypervitaminosis A syndrome; another major problem is that in some patients cancer cells become resistant to these compounds. The retinoid signal is mediated in target cells through specific nuclear receptors: the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RARs and RXRs are divergent in their ligand specificity; RA can bind and activate only RAR receptors, by contrast, 9-cis- retinoic acid binds RARs and RXRs, but with different affinities. It has been demonstrated that the retinoids that are ligands of RXR are efI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
