Several studies suggest the employment of retinoids in the therapy of cancer. These molecules, that are natural derivatives of vitamin A or retinol and include the all-trans-retinoic acid (RA), play important roles in modulating normal or tumor cell growth through the regulation of differentiation and/or apoptosis. The clinical use of retinoids is complicated by the fact that the doses needed for successful treatment are often toxic, leading to hypervitaminosis A syndrome; another major problem is that in some patients cancer cells become resistant to these compounds. The retinoid signal is mediated in target cells through specific nuclear receptors: the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RARs and RXRs are divergent in their ligand specificity; RA can bind and activate only RAR receptors, by contrast, 9-cis- retinoic acid binds RARs and RXRs, but with different affinities. It has been demonstrated that the retinoids that are ligands of RXR are ef

ANTITUMORAL EFFECT OF RETINOIDS: A COMPARISON BETWEEN ALL TRANS RETINOIC ACID AND IIF, A SPECIFIC LIGAND OF RXR

BARTOLINI, GIOVANNA;PAPI, ALESSIO;FERRERI, ANNA MARIA;ROCCHI, PAOLA;ORLANDI, MARINA
2007

Abstract

Several studies suggest the employment of retinoids in the therapy of cancer. These molecules, that are natural derivatives of vitamin A or retinol and include the all-trans-retinoic acid (RA), play important roles in modulating normal or tumor cell growth through the regulation of differentiation and/or apoptosis. The clinical use of retinoids is complicated by the fact that the doses needed for successful treatment are often toxic, leading to hypervitaminosis A syndrome; another major problem is that in some patients cancer cells become resistant to these compounds. The retinoid signal is mediated in target cells through specific nuclear receptors: the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RARs and RXRs are divergent in their ligand specificity; RA can bind and activate only RAR receptors, by contrast, 9-cis- retinoic acid binds RARs and RXRs, but with different affinities. It has been demonstrated that the retinoids that are ligands of RXR are ef
Vitamin A: new research
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123
G.Bartolini; A.Papi; K.Ammar; A.M.Ferreri; P.Rocchi; M.Orlandi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/46840
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