A greatly improved procedure for the preparation of long-chain α-ketopyridazines, a class of potent inhibitors of fatty acid amide hydrolase (FAAH), is described. This optimization study shows a great dependence of the yields of desired products on the pyrididazinyl lithium/Weinreb amide ratio and offers a general approach to this kind of compound.

Synthesis of 1-Oxo-1-(3-pyridazinyl) Derivatives - Potent Inhibitors of Fatty Acid Amide Hydrolase (FAAH): An Improved and Optimized Procedure

ROSINI, GOFFREDO;MAROTTA, EMANUELA;TINARELLI, ALESSANDRO;RIGHI, PAOLO
2007

Abstract

A greatly improved procedure for the preparation of long-chain α-ketopyridazines, a class of potent inhibitors of fatty acid amide hydrolase (FAAH), is described. This optimization study shows a great dependence of the yields of desired products on the pyrididazinyl lithium/Weinreb amide ratio and offers a general approach to this kind of compound.
G. Rosini; D. G. Andreotti; P. D’Ambrosio; E. Marotta; A. Tinarelli; P. Righi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/46731
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