Red blood cells, currently obtained from donors, represent the most common form of cell-based therapy. A better understanding of normal erythropoiesis is leading to improved multi-step protocols for the in vitro generation of fully mature red cells. The extensive in vitro expansion of embryonic erythroblasts and development of erythroid precursors as a potential transfusion product may help to deal with issues of scale and eventually find a place in the treatment of patients with acute and chronic anemias.
Franco Migliaccio, A.R., Palis, J. (2011). Blood in a dish: In vitro synthesis of red blood cells. DRUG DISCOVERY TODAY: DISEASE MECHANISMS, 8, 3-8 [10.1016/j.ddmec.2011.10.002].
Blood in a dish: In vitro synthesis of red blood cells.
FRANCO MIGLIACCIO, ANNA RITA;
2011
Abstract
Red blood cells, currently obtained from donors, represent the most common form of cell-based therapy. A better understanding of normal erythropoiesis is leading to improved multi-step protocols for the in vitro generation of fully mature red cells. The extensive in vitro expansion of embryonic erythroblasts and development of erythroid precursors as a potential transfusion product may help to deal with issues of scale and eventually find a place in the treatment of patients with acute and chronic anemias.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
