Purpose: We examined the effect of regular physical activity on plasma ghrelin concentration after onset of puberty in girls. In addition, we also examined the association of fasting plasma ghrelin concentration with various plasma biochemical , body composition, and anaerobic capacity variables in healthy adolescent girls. Method: fifty healthy schoolgirls ages 11 to 16 yr were divided either into a phsyically active (N = 25) or a physically inactive (N = 25) group. The physically active group consisted of swimmers who had trained on an average of 6.2 +/- 2. h.wk-1 for the last 2 yrs, whereas the inclusion criterion for the physically inactive group was the participation in physical education classes only. The subjects were matched for age (+/- 1 years) and body mass index (BMI +/- 2 kg.m-2). Maturation I group (14 matched pairs) included pubertal stages 2 and 3, and maturation II group (11 matched pairs ) included pubertal stages 4 and 5. Results: physically active girls had significantly higher (p < 0.05) mean plasma ghrelin levels than the physically incative girls (maturation I: 1152.1 +/- 312.9 vs 877+/- 114.8 pg.mL-1; maturation II: 1084 +/- 252.5 vs 793.4 +/- 164.9 pg.mL-1). Plasma ghrelin concentration was negatively related to percent body fat, fat mass, peak oxygen consumption per kilogram of body mass, leptin, estradiol, insulin, and insulin-like growth factor-I(IGF-I)(r > 0.298; P < 0.05). Multivariate linear regression analysis to determine ghrelin concentration using the variables that were significantly associated with ghrelin concentration demonstrated that plasma IGF-I was the most important predictor of plasma ghrelin concentration (b =-0.396; P = 0.008). Conclusion: regular physical activity influences plasma ghrelin concentration in girls with different pubertal maturation levels. Plasma IGF-I concentration seems to be the main determinant of circulating ghrelin in healthy, normal weight adolescent girls.
Jurimae J., Cicchella, Jurimae T., Latt E., Haljaste K., Purge P., et al. (2007). Regular Physical Activity Influences Plasma Ghrelin Concentration in Adolescent Girls. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 39 (10), 1736-1741.
Regular Physical Activity Influences Plasma Ghrelin Concentration in Adolescent Girls
CICCHELLA, ANTONIO;
2007
Abstract
Purpose: We examined the effect of regular physical activity on plasma ghrelin concentration after onset of puberty in girls. In addition, we also examined the association of fasting plasma ghrelin concentration with various plasma biochemical , body composition, and anaerobic capacity variables in healthy adolescent girls. Method: fifty healthy schoolgirls ages 11 to 16 yr were divided either into a phsyically active (N = 25) or a physically inactive (N = 25) group. The physically active group consisted of swimmers who had trained on an average of 6.2 +/- 2. h.wk-1 for the last 2 yrs, whereas the inclusion criterion for the physically inactive group was the participation in physical education classes only. The subjects were matched for age (+/- 1 years) and body mass index (BMI +/- 2 kg.m-2). Maturation I group (14 matched pairs) included pubertal stages 2 and 3, and maturation II group (11 matched pairs ) included pubertal stages 4 and 5. Results: physically active girls had significantly higher (p < 0.05) mean plasma ghrelin levels than the physically incative girls (maturation I: 1152.1 +/- 312.9 vs 877+/- 114.8 pg.mL-1; maturation II: 1084 +/- 252.5 vs 793.4 +/- 164.9 pg.mL-1). Plasma ghrelin concentration was negatively related to percent body fat, fat mass, peak oxygen consumption per kilogram of body mass, leptin, estradiol, insulin, and insulin-like growth factor-I(IGF-I)(r > 0.298; P < 0.05). Multivariate linear regression analysis to determine ghrelin concentration using the variables that were significantly associated with ghrelin concentration demonstrated that plasma IGF-I was the most important predictor of plasma ghrelin concentration (b =-0.396; P = 0.008). Conclusion: regular physical activity influences plasma ghrelin concentration in girls with different pubertal maturation levels. Plasma IGF-I concentration seems to be the main determinant of circulating ghrelin in healthy, normal weight adolescent girls.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
