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EnglishThis brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H2O2 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested
| Titolo: | Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line | |
| Autore/i: | HAKIM, GABRIELE; FIORENTINI, DIANA; Maraldi T.; LANDI, LAURA | |
| Autore/i Unibo: | ||
| Anno: | 2004 | |
| Rivista: | ||
| Abstract: | This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H2O2 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested | |
| Data prodotto definitivo in UGOV: | 2005-10-10 14:19:48 | |
| Data stato definitivo: | 2016-07-08T16:05:37Z | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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