This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H2O2 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested

Acute regulation of the facilitative glucose transporter GLUT1 in a hematopoietic cell line

HAKIM, GABRIELE;FIORENTINI, DIANA;LANDI, LAURA
2004

Abstract

This brief review is focused on the short-term regulation of the facilitative glucose transporter GLUT1 in megakaryocytic cells M07e. The effects of cytokines such as TPO, GM-CSF and SCF and of a low dose of H2O2 on the transport activity and its kinetic parameters are compared. The possible mechanisms and the signalling pathways involved in the glucose uptake activation are discussed. A role for the cellular redox status in glucose uptake control, possibly related to the status of redox-sensitive enzymes such as tyrosine phosphatases, is suggested
ITALIAN JOURNAL OF BIOCHEMISTRY
Hakim G.; Fiorentini D.; Maraldi T.; Landi L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/4504
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