The distinction between plasmablastic lymphoma (PBL) and plasmacytoma may be confidently made on the basis of histopathological and clinical features. However, some cases can be challenging owing to a morphological overlap. The main significant differences include genetic aberrations [i.e. t(11;14); t(4;14), hyperdiploidy], and in particular the presence of Epstein-Barr virus (EBV)-encoded RNA (EBER), which is detectable in 75–100% of all PBL cases, in contrast to plasmacytoma (10% of cases).1 The exact role of EBV in the pathogenesis of PBL is still poorly understood.2 Although it has been suggested that PBL may occur as a high-grade transformation from a pre-existing plasmacytoma following EBV infection, this concept has not been well established and definitive proof is lacking.
Ambrosio MR, De Falco G, Gozzetti A, Rocca BJ, Amato T, Mourmouras V, et al. (2014). Plasmablastic transformation of a pre-existing plasmacytoma: a possible role for reactivation of Epstein Barr virus infection. HAEMATOLOGICA, 99(11), 235-237 [10.3324/haematol.2014.111872].
Plasmablastic transformation of a pre-existing plasmacytoma: a possible role for reactivation of Epstein Barr virus infection.
PICCALUGA P.;
2014
Abstract
The distinction between plasmablastic lymphoma (PBL) and plasmacytoma may be confidently made on the basis of histopathological and clinical features. However, some cases can be challenging owing to a morphological overlap. The main significant differences include genetic aberrations [i.e. t(11;14); t(4;14), hyperdiploidy], and in particular the presence of Epstein-Barr virus (EBV)-encoded RNA (EBER), which is detectable in 75–100% of all PBL cases, in contrast to plasmacytoma (10% of cases).1 The exact role of EBV in the pathogenesis of PBL is still poorly understood.2 Although it has been suggested that PBL may occur as a high-grade transformation from a pre-existing plasmacytoma following EBV infection, this concept has not been well established and definitive proof is lacking.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
