The distinction between plasmablastic lymphoma (PBL) and plasmacytoma may be confidently made on the basis of histopathological and clinical features. However, some cases can be challenging owing to a morphological overlap. The main significant differences include genetic aberrations [i.e. t(11;14); t(4;14), hyperdiploidy], and in particular the presence of Epstein-Barr virus (EBV)-encoded RNA (EBER), which is detectable in 75–100% of all PBL cases, in contrast to plasmacytoma (10% of cases).1 The exact role of EBV in the pathogenesis of PBL is still poorly understood.2 Although it has been suggested that PBL may occur as a high-grade transformation from a pre-existing plasmacytoma following EBV infection, this concept has not been well established and definitive proof is lacking.
Plasmablastic transformation of a pre-existing plasmacytoma: a possible role for reactivation of Epstein Barr virus infection / Ambrosio MR;De Falco G;Gozzetti A;Rocca BJ;Amato T;Mourmouras V;Gazaneo S;Mundo L;Candi V;PICCALUGA P.;Cusi MG;Leoncini L;Lazzi S.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - ELETTRONICO. - 99:11(2014), pp. 235-237. [10.3324/haematol.2014.111872]
Plasmablastic transformation of a pre-existing plasmacytoma: a possible role for reactivation of Epstein Barr virus infection.
PICCALUGA P.;
2014
Abstract
The distinction between plasmablastic lymphoma (PBL) and plasmacytoma may be confidently made on the basis of histopathological and clinical features. However, some cases can be challenging owing to a morphological overlap. The main significant differences include genetic aberrations [i.e. t(11;14); t(4;14), hyperdiploidy], and in particular the presence of Epstein-Barr virus (EBV)-encoded RNA (EBER), which is detectable in 75–100% of all PBL cases, in contrast to plasmacytoma (10% of cases).1 The exact role of EBV in the pathogenesis of PBL is still poorly understood.2 Although it has been suggested that PBL may occur as a high-grade transformation from a pre-existing plasmacytoma following EBV infection, this concept has not been well established and definitive proof is lacking.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
