The chlorination of the carboxylic acid unit of alpha-aminoacids is an important reaction in organic synthesis, and the resulting compounds are usually seen as reactive intermediate species. Herein we report a straightforward procedure to obtain [MCl6](-) salts (M = Nb, 2a; Ta, 2b) of the L-proline-derivative (pyrrolidinium-2-carbonylchloride). These are stable up to 80 degrees C, in the solid state as well as in organic solvents. The X-ray structures determined for 2a, b include the first example of a crystallographically-characterized alpha-ammonium-acylchloride.

A simple route to thermally-stable salts of pyrrolidinium-2-carbonylchloride / Fabio Marchetti;Guido Pampaloni;Stefano Zacchini. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 4:(2014), pp. 60878-60882. [10.1039/C4RA12630K]

A simple route to thermally-stable salts of pyrrolidinium-2-carbonylchloride

ZACCHINI, STEFANO
2014

Abstract

The chlorination of the carboxylic acid unit of alpha-aminoacids is an important reaction in organic synthesis, and the resulting compounds are usually seen as reactive intermediate species. Herein we report a straightforward procedure to obtain [MCl6](-) salts (M = Nb, 2a; Ta, 2b) of the L-proline-derivative (pyrrolidinium-2-carbonylchloride). These are stable up to 80 degrees C, in the solid state as well as in organic solvents. The X-ray structures determined for 2a, b include the first example of a crystallographically-characterized alpha-ammonium-acylchloride.
2014
A simple route to thermally-stable salts of pyrrolidinium-2-carbonylchloride / Fabio Marchetti;Guido Pampaloni;Stefano Zacchini. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 4:(2014), pp. 60878-60882. [10.1039/C4RA12630K]
Fabio Marchetti;Guido Pampaloni;Stefano Zacchini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/420971
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