Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hosts
S. E. Evans, K. Leventakos, R. Ben-Ami, D. You, S. G. Thakkar, R. E. Lewis, et al. (2010). Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. Additional evidence of specificity to mammalian hosts. VIRULENCE, 1, 523-525 [10.4161/viru.1.6.13903].
Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. Additional evidence of specificity to mammalian hosts
LEWIS, RUSSEL EDWARD;
2010
Abstract
Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hostsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
