Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.
R. E. Lewis, G. N. Pongas, N. Albert, R. Ben-Ami, T. J. Walsh, D. P. Kontoyiannis (2011). Activity of Deferasirox in Mucorales: Influences of Species and Exogenous Iron. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55, 411-413 [10.1128/AAC.00792-10].
Activity of Deferasirox in Mucorales: Influences of Species and Exogenous Iron
LEWIS, RUSSEL EDWARD;
2011
Abstract
Differences in deferasirox susceptibility among members of the order Mucorales are unknown. Here we show that Cunninghamella bertholletiae (four isolates) and Mucor species (five isolates) display higher deferasirox MICs and minimal fungicidal concentrations compared to Rhizopus species (six isolates). Exogenous iron further attenuated the deferasirox susceptibility of Mucorales isolates with low MICs. Vital staining revealed damage to subapical compartments in susceptible strains.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
