Objective Perineural invasion (PNI) is frequent in oral squamous cell carcinoma (OSCC) and could play an important role in treatment decisions. Study Design This retrospective study used multivariate analysis to evaluate the impact of PNI on locoregional recurrence, neck metastases, and survival in 236 consecutive patients with oral cancer. Results There were significant differences in the local (P = .007) and regional (P = .041) failure rates in the PNI-positive group compared with the PNI-negative group. Univariate analysis demonstrated that PNI-positive patients had significantly worse locoregional control (P = .011), disease-specific survival (P = .023), and overall survival (P = .046) compared with PNI-negative patients. Conclusion PNI was an independent predictor of local and regional failure in a well-defined, homogeneous population with OSCC.
Impact of perineural invasion as independent prognostic factor for local and regional failure in oral squamous cell carcinoma / Achille Tarsitano; Maria Lucia Tardio; Claudio Marchetti. - In: ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY AND ORAL RADIOLOGY. - ISSN 2212-4403. - STAMPA. - 119:2(2015), pp. 221-228. [10.1016/j.oooo.2014.10.004]
Impact of perineural invasion as independent prognostic factor for local and regional failure in oral squamous cell carcinoma
TARSITANO, ACHILLE;MARCHETTI, CLAUDIO
2015
Abstract
Objective Perineural invasion (PNI) is frequent in oral squamous cell carcinoma (OSCC) and could play an important role in treatment decisions. Study Design This retrospective study used multivariate analysis to evaluate the impact of PNI on locoregional recurrence, neck metastases, and survival in 236 consecutive patients with oral cancer. Results There were significant differences in the local (P = .007) and regional (P = .041) failure rates in the PNI-positive group compared with the PNI-negative group. Univariate analysis demonstrated that PNI-positive patients had significantly worse locoregional control (P = .011), disease-specific survival (P = .023), and overall survival (P = .046) compared with PNI-negative patients. Conclusion PNI was an independent predictor of local and regional failure in a well-defined, homogeneous population with OSCC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
