We apply a recently developed model of cytoskeletal force generation to study a cell’s intrinsic contractility, as well as its response to external loading. The model is based on a nonequilibrium thermodynamic treatment of the mechanochemistry governing force in the stress fiber-focal adhesion system. Our computational study suggests that the mechanical coupling between the stress fibers and focal adhesions leads to a complex, dynamic, mechanochemical response. We collect the results in response maps whose regimes are distinguished by the initial geometry of the stress fiber-focal adhesion system, and by the external load on the cell. The results from our model connect qualitatively with recent studies on the force response of smooth muscle cells on arrays of polymeric microposts.
Maraldi M., Valero C., Garikipati K. (2014). A Computational Study of Stress Fiber-Focal Adhesion Dynamics Governing Cell Contractility. BIOPHYSICAL JOURNAL, 106(9), 1890-1901 [10.1016/j.bpj.2014.03.027].
A Computational Study of Stress Fiber-Focal Adhesion Dynamics Governing Cell Contractility
MARALDI, MIRKO;
2014
Abstract
We apply a recently developed model of cytoskeletal force generation to study a cell’s intrinsic contractility, as well as its response to external loading. The model is based on a nonequilibrium thermodynamic treatment of the mechanochemistry governing force in the stress fiber-focal adhesion system. Our computational study suggests that the mechanical coupling between the stress fibers and focal adhesions leads to a complex, dynamic, mechanochemical response. We collect the results in response maps whose regimes are distinguished by the initial geometry of the stress fiber-focal adhesion system, and by the external load on the cell. The results from our model connect qualitatively with recent studies on the force response of smooth muscle cells on arrays of polymeric microposts.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
