Factors involved in pollen germination could have a role also in allergic sensitization In pollen tubes, cytoskeleton proteins are involved in many aspects of pollen germination and growth, from the transport of sperm cells to the asymmetrical distribution of organelles to the deposition of cell wall material. These activities are based on the dynamics of the cytoskeleton. Transglutaminases catalyze the post-translational conjugation of polyamines to different protein targets, but also the cross-linking between endo-glutamine and -lysine protein residues; they are suggested to have a role in the interaction between pollen tubes and the extracellular matrix during fertilization and a specific role during the self-incompatibility response. In such processes, the activity of transglutaminase is enhanced, leading to the formation of cross-linked products; moreover, it could act as regulator of cytoskeleton dynamics. Different factors related to pollen germination and tube growth could be also involved in allergic sensitization. Among them, the phospholipase (PL), involved in the apex growth of the elongating pollen tube, is an integrator of the tip molecular signalling. The presence of phospholipase A2 has been recently described in pollen; being PLA2 able to generate pro-inflammatory factors, this enzyme could participate in the activation of the allergenic inflammatory cascade. It is also known that stimulation of PLA2 activity occurs when it is post-translationally modified by transglutaminase. Profilin is a known pan allergen and also a key factor to control actin filament organization, indeed the pollen tube growth. In some pollens has been observed that secretion of pro-inflammatory eicosanoid-like substances precedes allergens release from pollen grains in the initiation of allergic sensitization. Also tip-localized ROS were needed to sustain the normal rate of pollen tube growth as ROS disruption induced the pollen to programmed cell death. More studies are necessary to better know these factors and their importance in allergic sensitization.
Del Duca S, Iorio R, Serafini Fracassini D, Cai G (2013). Factors involved in pollen germination could have a role also in allergic sensitization. Madrid : Testillano P, Pardo C, Risueno M, Lopez-Cepero J.
Factors involved in pollen germination could have a role also in allergic sensitization
DEL DUCA, STEFANO;IORIO, ROSA ANNA;SERAFINI FRACASSINI, DONATELLA;
2013
Abstract
Factors involved in pollen germination could have a role also in allergic sensitization In pollen tubes, cytoskeleton proteins are involved in many aspects of pollen germination and growth, from the transport of sperm cells to the asymmetrical distribution of organelles to the deposition of cell wall material. These activities are based on the dynamics of the cytoskeleton. Transglutaminases catalyze the post-translational conjugation of polyamines to different protein targets, but also the cross-linking between endo-glutamine and -lysine protein residues; they are suggested to have a role in the interaction between pollen tubes and the extracellular matrix during fertilization and a specific role during the self-incompatibility response. In such processes, the activity of transglutaminase is enhanced, leading to the formation of cross-linked products; moreover, it could act as regulator of cytoskeleton dynamics. Different factors related to pollen germination and tube growth could be also involved in allergic sensitization. Among them, the phospholipase (PL), involved in the apex growth of the elongating pollen tube, is an integrator of the tip molecular signalling. The presence of phospholipase A2 has been recently described in pollen; being PLA2 able to generate pro-inflammatory factors, this enzyme could participate in the activation of the allergenic inflammatory cascade. It is also known that stimulation of PLA2 activity occurs when it is post-translationally modified by transglutaminase. Profilin is a known pan allergen and also a key factor to control actin filament organization, indeed the pollen tube growth. In some pollens has been observed that secretion of pro-inflammatory eicosanoid-like substances precedes allergens release from pollen grains in the initiation of allergic sensitization. Also tip-localized ROS were needed to sustain the normal rate of pollen tube growth as ROS disruption induced the pollen to programmed cell death. More studies are necessary to better know these factors and their importance in allergic sensitization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
