A novel, multicomponent and stereoselective approach to functionalized indane derivatives is reported. It is based on a tandem process consisting of Pd-catalyzed oxidative carbamoylation of 2-(2-ethynylbenzyl) malonates with carbon monoxide, a secondary amine, and oxygen (with formation of a propiolamide intermediate), followed by carbocyclization, occurring through intramolecular addition of an in situ formed carbanion to the propiolamide moiety.
Cascade Reactions: A Multicomponent Approach to Functionalized Indane Derivatives by a Tandem Palladium-Catalyzed Carbamoylation / Carbocylization Process / B. Gabriele; L. Veltri; R. Mancuso; C. Carfagna. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4150. - STAMPA. - 356:(2014), pp. 2547-2558. [10.1002/adsc.201301051]
Cascade Reactions: A Multicomponent Approach to Functionalized Indane Derivatives by a Tandem Palladium-Catalyzed Carbamoylation / Carbocylization Process
CARFAGNA, CARLA
2014
Abstract
A novel, multicomponent and stereoselective approach to functionalized indane derivatives is reported. It is based on a tandem process consisting of Pd-catalyzed oxidative carbamoylation of 2-(2-ethynylbenzyl) malonates with carbon monoxide, a secondary amine, and oxygen (with formation of a propiolamide intermediate), followed by carbocyclization, occurring through intramolecular addition of an in situ formed carbanion to the propiolamide moiety.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.