In the presence of a thiourea catalyst, b-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of b-CF3 amine precursors with a tertiary stereocentre at the b-position. This reaction represents the first general catalytic enantioselective approach to this important class of b-CF3 amines.
Emilie Martinelli, Anna Chiara Vicini, Michele Mancinelli, Andrea Mazzanti, Paolo Zani, Luca Bernardi, et al. (2015). Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines. CHEMICAL COMMUNICATIONS, 51, 658-660 [10.1039/C4CC07801B].
Catalytic highly enantioselective transfer hydrogenation of β-trifluoromethyl nitroalkenes. An easy and general entry to optically active β-trifluoromethyl amines
MANCINELLI, MICHELE;MAZZANTI, ANDREA;ZANI, PAOLO;BERNARDI, LUCA;FOCHI, MARIAFRANCESCA
2015
Abstract
In the presence of a thiourea catalyst, b-CF3 nitroalkenes react with Hantzsch esters in a highly enantioselective fashion, giving a broad range of b-CF3 amine precursors with a tertiary stereocentre at the b-position. This reaction represents the first general catalytic enantioselective approach to this important class of b-CF3 amines.| File | Dimensione | Formato | |
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C4CC07801B corrected proof.pdf
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