The organocatalytic asymmetric α-alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts, α- diarylmethine-substituted aldehydes with two contiguous stereocenters have been synthesized in a simple manner with good diastereocontrol and excellent enantioselectivity.

A New Organocatalytic Concept for Asymmetric α-Alkylation of Aldehydes

CARUANA, LORENZO;
2014

Abstract

The organocatalytic asymmetric α-alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts, α- diarylmethine-substituted aldehydes with two contiguous stereocenters have been synthesized in a simple manner with good diastereocontrol and excellent enantioselectivity.
2014
Lorenzo Caruana;Florian Kniep;Tore Kiilerich Johansen;Pernille H. Poulsen;Karl Anker Jørgensen
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/396718
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