Effectiveness of an ozonated essential oil as adjunctive in non surgical periodontal therapy. A pilot study.

Aim The aim of this study is to analyze the properties of ozonated sunflower oil (Oleozon) as adjunctive in non surgical periodontal therapy. It is proposed to compare results of traditional scaling and root planning (C:control) against scaling and root planning with pocket irrigation and topical application of ozonated sunflower oil (T:test). Results will be determinate according to probing pocket depth (PPD) at baseline and 1 month following initial therapy. Material and methods 384 sites were randomly assigned to T and 402 to C, according to split mouth design on 5 patients. Shapiro-Wilk’s test verified that distribution was not gaussian. Percentage rates (PPD at 1-month/PPD at baseline) ± standard error were used to describe data. T and C were compared using Wilcoxon test for paired samples. According to PPD, data were divided in 3 groups (0-3mm, 4-6mm, >7mm) and evaluated by the Kruskal-Wallis analysis of variance. Alpha level was set at 0.05. Results The decrease of PPD between baseline and 1-month for T was 33.19% and 25.21% for C; this difference was statistically significant (Wilcoxon test: Z=-7.914, p=0.0001). PPD media at baseline was 5.76±0.10 for T and 5.30±0.09 for C; at 1 month it was 3.82±0.07 and 3.87±0.07 respectively. Mean PPD decreased of 1.94mm [95%confidence interval (CI) 1.88-2.08] in T and of 1.34mm (CI 1.30-1.51) in C. The decrease of PPD between baseline and 1-month was significant in all 3 groups of PPD (p=0.0001), but higher in T. The bigger difference in PPD reduction when comparing T against C was observed in shallower pockets. Conclusion With the limitation of this study, the adjunctive use of ozonated oil during initial preparation demonstrated significant clinical benefits in a short period when compared with S-RP alone.