The PRKAG3 gene encodes for the regulatory gamma 3 subunit of adenosine monophosfate-activated protein kinase (AMPK) protein that plays a relevant role as regulator of carbohydrate and fat metabolism in mammalian skeletal muscle cells. Several single nucleotide polymorphisms (SNPs) in the porcine PRKAG3 gene have been previously identified. Two missense mutations (c.595A>G and c.599G>A, giving p.I199V and p.R200Q aminoacid substitutions, respectively) were the most studied in different pig breeds and populations and have been associated with meat and carcass traits. Pigs that carry the dominant c.599A allele (p.200Q or allele RN-) have excessive skeletal muscle glycogen content and give the so-called acid meat (also referred to as Hampshire type meat). So far, the p.200Q allele has been identified in Hampshire and Hampshire derived lines. The c.595A>G SNP has been associated with variation of numerous traits including water holding capacity, pH, colour, carcass composition, and several
Dall’Olio S., Scotti E., Nanni Costa L., D’Alessandro E., Russo V., Fontanesi L. (2013). Analysis of PRKAG3 gene polymorphisms in Italian local pig breeds. ITALIAN JOURNAL OF ANIMAL SCIENCE, 12(Suppl. 1), 70-70.
Analysis of PRKAG3 gene polymorphisms in Italian local pig breeds
DALL'OLIO, STEFANIA;SCOTTI, EMILIO;NANNI COSTA, LEONARDO;RUSSO, VINCENZO;FONTANESI, LUCA
2013
Abstract
The PRKAG3 gene encodes for the regulatory gamma 3 subunit of adenosine monophosfate-activated protein kinase (AMPK) protein that plays a relevant role as regulator of carbohydrate and fat metabolism in mammalian skeletal muscle cells. Several single nucleotide polymorphisms (SNPs) in the porcine PRKAG3 gene have been previously identified. Two missense mutations (c.595A>G and c.599G>A, giving p.I199V and p.R200Q aminoacid substitutions, respectively) were the most studied in different pig breeds and populations and have been associated with meat and carcass traits. Pigs that carry the dominant c.599A allele (p.200Q or allele RN-) have excessive skeletal muscle glycogen content and give the so-called acid meat (also referred to as Hampshire type meat). So far, the p.200Q allele has been identified in Hampshire and Hampshire derived lines. The c.595A>G SNP has been associated with variation of numerous traits including water holding capacity, pH, colour, carcass composition, and severalI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
