BACKGROUND/AIMS: In some randomized controlled trials laparoscopic cholecystectomy (LC) for acute cholecystitis was associated with a shorter hospital stay when compared with open cholecystectomy (OC). These studies were not double blinded and without intention to treat purpose. METHODOLOGY: The present study project was a prospective, randomized investigation. The study was performed in the Department of General, Emergency and Transplant Surgery St Orsola-Malpighi University Hospital (Bologna, Italy). Subjects were divided in two groups: in the first group the patient was submitted to LC while in the second group was submitted to OC. RESULTS: Of 164 consecutive patients, 20 were excluded from the study. The two groups were similar in demographic and clinical characteristics. Seven (9.7%) patients in the LC group required conversion to OC. There were no deaths or bile duct lesions in either group, and the postoperative complication rate was similar (p=n.s.). The mean postoperative hospital stay was also comparable. CONCLUSIONS: Even though LC for acute and gangrenous cholecystitis is technically demanding, in experienced hands it is safe and effective. It does not increase the mortality and the morbidity rate with a low conversion rate and no difference in hospital stay.

The ACTIVE (Acute Cholecystitis Trial Invasive Versus Endoscopic) Study: multicenter randomized, double-blind, controlled trial of laparoscopic versus open surgery for acute cholecystitis / Catena F;Ansaloni L;Bianchi E;Di Saverio S;Coccolini F;Vallicelli C;Lazzareschi D;Sartelli M;Amaduzzi A;Amaduzz A;Pinna AD. - In: HEPATO-GASTROENTEROLOGY. - ISSN 0172-6390. - STAMPA. - 60:127(2013), pp. 1552-1556.

The ACTIVE (Acute Cholecystitis Trial Invasive Versus Endoscopic) Study: multicenter randomized, double-blind, controlled trial of laparoscopic versus open surgery for acute cholecystitis.

CATENA, FAUSTO;PINNA, ANTONIO DANIELE
2013

Abstract

BACKGROUND/AIMS: In some randomized controlled trials laparoscopic cholecystectomy (LC) for acute cholecystitis was associated with a shorter hospital stay when compared with open cholecystectomy (OC). These studies were not double blinded and without intention to treat purpose. METHODOLOGY: The present study project was a prospective, randomized investigation. The study was performed in the Department of General, Emergency and Transplant Surgery St Orsola-Malpighi University Hospital (Bologna, Italy). Subjects were divided in two groups: in the first group the patient was submitted to LC while in the second group was submitted to OC. RESULTS: Of 164 consecutive patients, 20 were excluded from the study. The two groups were similar in demographic and clinical characteristics. Seven (9.7%) patients in the LC group required conversion to OC. There were no deaths or bile duct lesions in either group, and the postoperative complication rate was similar (p=n.s.). The mean postoperative hospital stay was also comparable. CONCLUSIONS: Even though LC for acute and gangrenous cholecystitis is technically demanding, in experienced hands it is safe and effective. It does not increase the mortality and the morbidity rate with a low conversion rate and no difference in hospital stay.
2013
The ACTIVE (Acute Cholecystitis Trial Invasive Versus Endoscopic) Study: multicenter randomized, double-blind, controlled trial of laparoscopic versus open surgery for acute cholecystitis / Catena F;Ansaloni L;Bianchi E;Di Saverio S;Coccolini F;Vallicelli C;Lazzareschi D;Sartelli M;Amaduzzi A;Amaduzz A;Pinna AD. - In: HEPATO-GASTROENTEROLOGY. - ISSN 0172-6390. - STAMPA. - 60:127(2013), pp. 1552-1556.
Catena F;Ansaloni L;Bianchi E;Di Saverio S;Coccolini F;Vallicelli C;Lazzareschi D;Sartelli M;Amaduzzi A;Amaduzz A;Pinna AD
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/394719
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