We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.
Recurrent gastrointestinal hemorrhage in treatment with dasatinib in a patient showing SMAD4 mutation with acute lymphoblastic leukemia Philadelphia positive and juvenile polyposis hereditary hemorrhagic telangiectasia syndrome / Chiara Sartor;Cristina Papayannidis;Maria Chiara Abbenante;Ilaria Iacobucci;Alessandro Broccoli;Claudia Venturi;Nicoletta Testoni;Anna Ferrari;Giovanni Martinelli. - In: HEMATOLOGY REPORTS. - ISSN 2038-8330. - STAMPA. - 5:2(2013), pp. 26-27. [10.4081/hr.2013.e7]
Recurrent gastrointestinal hemorrhage in treatment with dasatinib in a patient showing SMAD4 mutation with acute lymphoblastic leukemia Philadelphia positive and juvenile polyposis hereditary hemorrhagic telangiectasia syndrome
SARTOR, CHIARA;PAPAYANNIDIS, CRISTINA;ABBENANTE, MARIACHIARA;IACOBUCCI, ILARIA;BROCCOLI, ALESSANDRO;VENTURI, CLAUDIA;TESTONI, NICOLETTA;FERRARI, ANNA;MARTINELLI, GIOVANNI
2013
Abstract
We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.File | Dimensione | Formato | |
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