Aim: To analyze the results of extracranial stereotactic radiotherapy (ESRT) experience in pancreatic cancer patients. Methods: Four noncoplanar fixed beams were used in all patients. Results: Analysis of 16 patients was carried out. Overall response rate was 56.2%. Fifteen patients experienced local and/or distant progression of disease (median follow-up: 24 months). Two-year local progression-free, distant progression-free, and overall survivals were 85.7%, 58.7%, and 50.0%, respectively. Toxicity was less than grade 2 in all, although 1 patient had severe duodenal bleeding. Quality of life scores were unchanged. Conclusions: ESRT was associated with low complication rate, and not worsening the patients' quality of life.
Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors: a case series / Macchia G; Morganti AG; Cilla S; Ippolito E; Massaccesi M; Picardi V; Mattiucci GC; Bonomo P; Tambaro R; Pacelli F; Piermattei A; De Spirito M; Valentini V; Cellini N; Deodato F.. - In: CANCER INVESTIGATION. - ISSN 0735-7907. - ELETTRONICO. - 30:2(2012), pp. 149-155. [10.3109/07357907.2011.640649]
Quality of life and toxicity of stereotactic radiotherapy in pancreatic tumors: a case series
MORGANTI, ALESSIO GIUSEPPE;
2012
Abstract
Aim: To analyze the results of extracranial stereotactic radiotherapy (ESRT) experience in pancreatic cancer patients. Methods: Four noncoplanar fixed beams were used in all patients. Results: Analysis of 16 patients was carried out. Overall response rate was 56.2%. Fifteen patients experienced local and/or distant progression of disease (median follow-up: 24 months). Two-year local progression-free, distant progression-free, and overall survivals were 85.7%, 58.7%, and 50.0%, respectively. Toxicity was less than grade 2 in all, although 1 patient had severe duodenal bleeding. Quality of life scores were unchanged. Conclusions: ESRT was associated with low complication rate, and not worsening the patients' quality of life.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
