Background and purpose: Late rectal complications are assessed according to different scoring systems. Endoscopy can provide a more sensitive estimation of early radiation damage. The aim of this paper is to investigate the correlation between dosimetric parameters and rectal mucosal changes after radiotherapy (RT). Materials and methods: Patients with prostate adenocarcinoma treated with curative or adjuvant RT underwent endoscopy 1 year after RT. Receiver operating characteristics (ROC) analysis was performed to analyze the predictive capability of the dosimetric variables in determining mucosal changes classified by Vienna Rectoscopy Score (VRS). Results: The best dosimetric predictors of grade ≥2 telangiectasia were rectal (r) V 60 Gy (p = 0.014), rV 70 Gy (p = 0.017) and rD mean (p = 0.018). Similar results were obtained for grade ≥2 VRS. The set of rV 60 Gy < 34.4%, rV 70 Gy < 16.7% and rD mean < 57.5 Gy was associated with a decreased risk of grade ≥2 telangiectasia and VRS. Conclusions: rV 60 Gy, rV 70 Gy and rD mean were the strongest predictors of rectal mucosal alterations. In-depth analysis is required to correlate each mucosal alteration with late rectal toxicity in order to suggest early proctoscopy as surrogate end-point for rectal late toxicity in studies aimed at reducing this important complication.
Ippolito E, Deodato F, Macchia G, Massaccesi M, Digesù C, Pirozzi GA, et al. (2012). Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters. RADIOTHERAPY AND ONCOLOGY, 104(1), 103-108 [10.1016/j.radonc.2012.05.010].
Early radiation-induced mucosal changes evaluated by proctoscopy: Predictive role of dosimetric parameters.
MORGANTI, ALESSIO GIUSEPPE
2012
Abstract
Background and purpose: Late rectal complications are assessed according to different scoring systems. Endoscopy can provide a more sensitive estimation of early radiation damage. The aim of this paper is to investigate the correlation between dosimetric parameters and rectal mucosal changes after radiotherapy (RT). Materials and methods: Patients with prostate adenocarcinoma treated with curative or adjuvant RT underwent endoscopy 1 year after RT. Receiver operating characteristics (ROC) analysis was performed to analyze the predictive capability of the dosimetric variables in determining mucosal changes classified by Vienna Rectoscopy Score (VRS). Results: The best dosimetric predictors of grade ≥2 telangiectasia were rectal (r) V 60 Gy (p = 0.014), rV 70 Gy (p = 0.017) and rD mean (p = 0.018). Similar results were obtained for grade ≥2 VRS. The set of rV 60 Gy < 34.4%, rV 70 Gy < 16.7% and rD mean < 57.5 Gy was associated with a decreased risk of grade ≥2 telangiectasia and VRS. Conclusions: rV 60 Gy, rV 70 Gy and rD mean were the strongest predictors of rectal mucosal alterations. In-depth analysis is required to correlate each mucosal alteration with late rectal toxicity in order to suggest early proctoscopy as surrogate end-point for rectal late toxicity in studies aimed at reducing this important complication.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
