Multiple sclerosis (MS) is an inflammatory neurological disease that is widely regarded as the outcome of complex interactions between a genetic predisposition and an environmental trigger. Epstein-Barr virus (EBV) has recently been associated with the onset of MS, yet understanding how it elicits autoimmunity remains elusive. Neuroinflammation, including the entry of autoreactive T cells, likely follows a breach of the blood-brain barrier (BBB) leading to CNS lesions in MS. We show that EBV can infect human BBB cells leading to increased production of pro-inflammatory mediators that result in immune cell adherence thus modeling a key step in MS pathogenesis
Epstein-Barr virus infection of human brain microvessel endothelial cells: A novel role in multiple sclerosis / Costanza Casiraghi;Katerina Dorovini-Zis;Marc S. Horwitz. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - STAMPA. - 230:(2011), pp. 173-177. [10.1016/j.jneuroim.2010.08.003]
Epstein-Barr virus infection of human brain microvessel endothelial cells: A novel role in multiple sclerosis
CASIRAGHI, COSTANZA;
2011
Abstract
Multiple sclerosis (MS) is an inflammatory neurological disease that is widely regarded as the outcome of complex interactions between a genetic predisposition and an environmental trigger. Epstein-Barr virus (EBV) has recently been associated with the onset of MS, yet understanding how it elicits autoimmunity remains elusive. Neuroinflammation, including the entry of autoreactive T cells, likely follows a breach of the blood-brain barrier (BBB) leading to CNS lesions in MS. We show that EBV can infect human BBB cells leading to increased production of pro-inflammatory mediators that result in immune cell adherence thus modeling a key step in MS pathogenesisI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.