Twenty-nine canine mammary samples (5 normal mammary glands, 3 atypical ductal hyperplasia, 8 benign and 13 malignant tumors) were tested by immunohistochemistry (IHC) and Western Blot (WB) for E-cadherin. Both methods revealed a reduction of protein expression as the most important finding. A significant reduction of expression was revealed in dysplastic as well in benign and malignant neoplastic samples. The two methods revealed a significant correlation and absence of IHC false negative evaluation when the data of WB were corrected for the amounts of epithelial cells of the sample.

Determinazione immunoistochimica e western blot della caderina “E” nei tumori mammari della cagna

BRUNETTI, BARBARA;SARLI, GIUSEPPE;BERNARDINI, CHIARA;FORNI, MONICA;BENAZZI, CINZIA
2004

Abstract

Twenty-nine canine mammary samples (5 normal mammary glands, 3 atypical ductal hyperplasia, 8 benign and 13 malignant tumors) were tested by immunohistochemistry (IHC) and Western Blot (WB) for E-cadherin. Both methods revealed a reduction of protein expression as the most important finding. A significant reduction of expression was revealed in dysplastic as well in benign and malignant neoplastic samples. The two methods revealed a significant correlation and absence of IHC false negative evaluation when the data of WB were corrected for the amounts of epithelial cells of the sample.
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BRUNETTI B.; SARLI G.; BERNARDINI C.; FORNI M.; BENAZZI C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/3809
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