The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated. This derivative forms, with high fidelity, a dodecameric complex composed of three stacked G-quartets in the presence of strontium picrate. This is the first example of a fully-anti lipophilic G-quadruplex.

A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine

PIERACCINI, SILVIA;MASIERO, STEFANO;
2014

Abstract

The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated. This derivative forms, with high fidelity, a dodecameric complex composed of three stacked G-quartets in the presence of strontium picrate. This is the first example of a fully-anti lipophilic G-quadruplex.
Silvia Pieraccini; Michael A. Terzidis; Baldassarri Enrico J.; Fragneto Giovanna; Mariani Paolo; Masiero Stefano; Chryssostomos Chatgilialoglu
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/378285
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