The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated. This derivative forms, with high fidelity, a dodecameric complex composed of three stacked G-quartets in the presence of strontium picrate. This is the first example of a fully-anti lipophilic G-quadruplex.
A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine / Silvia Pieraccini; Michael A. Terzidis; Baldassarri Enrico J.; Fragneto Giovanna; Mariani Paolo; Masiero Stefano; Chryssostomos Chatgilialoglu. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - STAMPA. - 50:(2014), pp. 10722-10725. [10.1039/C4CC04275A]
A lipophilic “fully-anti” dodecamer from a (5′S)-5′,8-cyclo-2′-deoxyguanosine
PIERACCINI, SILVIA;MASIERO, STEFANO;
2014
Abstract
The self-assembly of a lipophilic derivative of (5'S)-5',8-cyclo-2'-deoxyguanosine, a mutagenic product formed by hydroxyl radical attack against DNA, has been investigated. This derivative forms, with high fidelity, a dodecameric complex composed of three stacked G-quartets in the presence of strontium picrate. This is the first example of a fully-anti lipophilic G-quadruplex.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
