Three sets of oligomers containing the 4-carboxy-5-methyl-oxazolidin-2-one (Oxd) moiety have been synthesized with the aim of checking whether these molecules are able to fold in ordered structures: A set [Boc-(L-Ala-L-Oxd)n-OR], B set [Boc-(L-Ala-D-Oxd)n-OR] and C set [Boc-(Aib-L-Oxd)n-OR] preferential conformations have been analyzed with IR absorption, NMR and CD. We have noticed that in these oligomers three stabilizing effects are active: (i) the rigid Oxd –CO-N(CH

C. Tomasini, G. Luppi, M. Monari (2006). Oxazolidin-2-ones-Containing Pseudopeptides that Fold into beta-Bend Ribbon Spirals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128, 2410-2420 [10.1021/ja056762h].

Oxazolidin-2-ones-Containing Pseudopeptides that Fold into beta-Bend Ribbon Spirals

TOMASINI, CLAUDIA;LUPPI, GIANLUIGI;MONARI, MAGDA
2006

Abstract

Three sets of oligomers containing the 4-carboxy-5-methyl-oxazolidin-2-one (Oxd) moiety have been synthesized with the aim of checking whether these molecules are able to fold in ordered structures: A set [Boc-(L-Ala-L-Oxd)n-OR], B set [Boc-(L-Ala-D-Oxd)n-OR] and C set [Boc-(Aib-L-Oxd)n-OR] preferential conformations have been analyzed with IR absorption, NMR and CD. We have noticed that in these oligomers three stabilizing effects are active: (i) the rigid Oxd –CO-N(CH
2006
C. Tomasini, G. Luppi, M. Monari (2006). Oxazolidin-2-ones-Containing Pseudopeptides that Fold into beta-Bend Ribbon Spirals. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128, 2410-2420 [10.1021/ja056762h].
C. Tomasini; G. Luppi; M. Monari
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/37297
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