Three sets of oligomers containing the 4-carboxy-5-methyl-oxazolidin-2-one (Oxd) moiety have been synthesized with the aim of checking whether these molecules are able to fold in ordered structures: A set [Boc-(L-Ala-L-Oxd)n-OR], B set [Boc-(L-Ala-D-Oxd)n-OR] and C set [Boc-(Aib-L-Oxd)n-OR] preferential conformations have been analyzed with IR absorption, NMR and CD. We have noticed that in these oligomers three stabilizing effects are active: (i) the rigid Oxd –CO-N(CH
Oxazolidin-2-ones-Containing Pseudopeptides that Fold into beta-Bend Ribbon Spirals
TOMASINI, CLAUDIA;LUPPI, GIANLUIGI;MONARI, MAGDA
2006
Abstract
Three sets of oligomers containing the 4-carboxy-5-methyl-oxazolidin-2-one (Oxd) moiety have been synthesized with the aim of checking whether these molecules are able to fold in ordered structures: A set [Boc-(L-Ala-L-Oxd)n-OR], B set [Boc-(L-Ala-D-Oxd)n-OR] and C set [Boc-(Aib-L-Oxd)n-OR] preferential conformations have been analyzed with IR absorption, NMR and CD. We have noticed that in these oligomers three stabilizing effects are active: (i) the rigid Oxd –CO-N(CHFile in questo prodotto:
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