BRAF alterations, namely BRAF fusion and BRAF V600E mutation, have been recently reported in low-grade epilepsy-associated tumors. Twenty low-grade epilepsy-associated tumors were retrieved to evaluate the BRAF mutational status. BRAF mutations were present in 10 tumors and concomitantly in associated dysplastic tissue of three patients. We here show for the first time that BRAF mutations are present not only in low-grade epilepsy-associated tumors but, in some cases, also in the associated focal cortical dysplasia.
Mutant BRAF in low-grade epilepsy-associated tumors and focal cortical dysplasia / Marucci G;de Biase D;Visani M;Giulioni M;Martinoni M;Volpi L;Riguzzi P;Rubboli G;Michelucci R;Tallini G. - In: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. - ISSN 2328-9503. - ELETTRONICO. - 1:2(2014), pp. 130-134. [10.1002/acn3.31]
Mutant BRAF in low-grade epilepsy-associated tumors and focal cortical dysplasia.
DE BIASE, DARIO;VISANI, MICHELA;TALLINI, GIOVANNI
2014
Abstract
BRAF alterations, namely BRAF fusion and BRAF V600E mutation, have been recently reported in low-grade epilepsy-associated tumors. Twenty low-grade epilepsy-associated tumors were retrieved to evaluate the BRAF mutational status. BRAF mutations were present in 10 tumors and concomitantly in associated dysplastic tissue of three patients. We here show for the first time that BRAF mutations are present not only in low-grade epilepsy-associated tumors but, in some cases, also in the associated focal cortical dysplasia.| File | Dimensione | Formato | |
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