Progesterone rapidly dissolves in an aqueous solution containing hydroxypropyl-β-cyclodextrin (HPBCD) at 1:2 molar ratio, forming a soluble inclusion complex. The solid complex was obtained by freeze-drying the final solution, after filtration. The solid complex was examined by differential scanning calorimetry, thermogravimetry, X-ray diffractions, Raman and FTIR spectroscopy. Experimental results confirm that a 1:2 inclusion complex exists in the solid state and is formed by insertion of the two ends if a single progesterone molecule into the cavity of two HPBCD molecules.
Solid State Characterization of Progesterone in a Freeze Dried 1:2 Progesterone/Hpbcd Mixture / G.ZOPPETTI; N. PUPPINI; F. OSPITALI; A. FINI. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - STAMPA. - 96:(2007), pp. 1729-1736. [10.1002/jps.20671]
Solid State Characterization of Progesterone in a Freeze Dried 1:2 Progesterone/Hpbcd Mixture
OSPITALI, FRANCESCA;FINI, ADAMO
2007
Abstract
Progesterone rapidly dissolves in an aqueous solution containing hydroxypropyl-β-cyclodextrin (HPBCD) at 1:2 molar ratio, forming a soluble inclusion complex. The solid complex was obtained by freeze-drying the final solution, after filtration. The solid complex was examined by differential scanning calorimetry, thermogravimetry, X-ray diffractions, Raman and FTIR spectroscopy. Experimental results confirm that a 1:2 inclusion complex exists in the solid state and is formed by insertion of the two ends if a single progesterone molecule into the cavity of two HPBCD molecules.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
