Scientific Opinion on the safety and efficacy of L-valine produced by Corynebacterium glutamicum (KCCM 80058) for all animal species, based on a dossier submitted by CJ Europe GmbH

L-Valine is a feed additive produced by a genetically modified strain of Corynebacterium glutamicum. Neither the production strain nor its recombinant DNA was found in the final product. The final product does not raise any safety concern with regard to the genetic modifications. L-Valine is safe for all target animals when added in appropriate amounts to diets. However, the FEEDAP Panel has concerns over the safety of L-valine for target species when administered via water for drinking since any additional supply of an essential amino acid would disturb the balanced amino acid pattern of complete diets. When used in animal nutrition, L-valine will be incorporated into the protein of the body of the target animal, and any potential excess will be metabolised and excreted. Considering the high purity of the product under assessment, and the lack of toxicological effects at likely use levels, no risks are expected for the consumer from the use L-valine as a feed additive. The L-valine produced by such strain of C. glutamicum has been shown not to be an irritant or a dermal sensitiser. The results of an acute inhalation study performed at high concentration show no evidence of significant acute toxicity by this route. Exposure of users by inhalation cannot be excluded. L-Valine is a natural constituent of plants and animals. Its use in animal nutrition does not represent a risk to the environment. L-Valine is efficacious as a supplemented amino acid to maintain or restore the adequate balance of amino acids for animal nutrition. A response in ruminants requires some degree of protection of L-valine from ruminal degradation.