The arylidene malonates with two different geminal carboxylate functions, a suitable class of substrates of several synthetic and pharmacological studies, are easily available through Knoevenagel condensation of ethyl tert-butyl malonate and different aromatic aldehydes. The results have increased the potentialities of CeCl3Æ7H2O–NaI system as a type of water-tolerant green Lewis acid promoter for carbon–carbon bond forming procedures.
G. Bartoli, R. Beleggia, S. Giuli, A. Giuliani, E. Marcantoni, M. Massaccesi, et al. (2006). The CeCl3.7H2O-NaI system as promoter in the synthesis of functionalized trisubstituted alkenes via Knoevenagel condensation. TETRAHEDRON LETTERS, 47, 6501-6504 [10.1016/j.tetlet.2006.07.031].
The CeCl3.7H2O-NaI system as promoter in the synthesis of functionalized trisubstituted alkenes via Knoevenagel condensation.
BARTOLI, GIUSEPPE;
2006
Abstract
The arylidene malonates with two different geminal carboxylate functions, a suitable class of substrates of several synthetic and pharmacological studies, are easily available through Knoevenagel condensation of ethyl tert-butyl malonate and different aromatic aldehydes. The results have increased the potentialities of CeCl3Æ7H2O–NaI system as a type of water-tolerant green Lewis acid promoter for carbon–carbon bond forming procedures.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
