The first Lewis acid catalyzed protection of alcohols as Boc derivatives is described. Zinc acetate is a very efficient catalyst for this transformation and the reaction can be applied to primary, secondary and aromatic alcohols, providing the first example of a generally applicable method.
The First Simple Method of Protection of Hydroxy Compounds as their O-Boc Derivatives under Lewis Acid Catalysis / G. Bartoli; M. Bosco; A. Carlone; R. Dalpozzo; M. Locatelli; P. Melchiorre; P. Palazzi; L. Sambri. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - /:(2006), pp. 2104-2108. [10.1055/s-2006-949609]
The First Simple Method of Protection of Hydroxy Compounds as their O-Boc Derivatives under Lewis Acid Catalysis
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;CARLONE, ARMANDO;LOCATELLI, MANUELA;MELCHIORRE, PAOLO;PALAZZI, PAOLO;SAMBRI, LETIZIA
2006
Abstract
The first Lewis acid catalyzed protection of alcohols as Boc derivatives is described. Zinc acetate is a very efficient catalyst for this transformation and the reaction can be applied to primary, secondary and aromatic alcohols, providing the first example of a generally applicable method.File in questo prodotto:
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