In leukemic cells, glucose transport is activated by SCF and H 2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.
Glucose-Transport Regulation in Leukemic Cells: How can H2O2 mimic Stem Cell Factor effects? / Maraldi T.; Fiorentini D.; Prata C.; Landi L.; Hakim G.. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - STAMPA. - 9:(2007), pp. 271-279. [10.1089/ars.2007.9.271]
Glucose-Transport Regulation in Leukemic Cells: How can H2O2 mimic Stem Cell Factor effects?
FIORENTINI, DIANA;PRATA, CECILIA;LANDI, LAURA;HAKIM, GABRIELE
2007
Abstract
In leukemic cells, glucose transport is activated by SCF and H 2O2 through a common signal cascade involving Akt, PLCγ, Syk, and the Src family, in this order. An explanation can be provided by the phosphorylation of c-kit, the SCF receptor, elicited by either SCF or H2O2. Moreover, antioxidants prevent the SCF effect on glucose transport, confirming the involvement of H2O2 in the pathway leading to glucose-transport activation and suggesting a potential role for reactive oxygen species in leukemia proliferation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
