The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.
Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa / Piazzi G; Paterini P; Ceccarelli C; Pantaleo MA; Biasco G. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - STAMPA. - 95:(2006), pp. 1525-1528. [10.1038/sj.bjc.6603441]
Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa
Piazzi G;PATERINI, PAOLA;CECCARELLI, CLAUDIO;PANTALEO, MARIA ABBONDANZA;BIASCO, GUIDO
2006
Abstract
The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
