The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.
Piazzi G, Paterini P, Ceccarelli C, Pantaleo MA, Biasco G (2006). Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa. BRITISH JOURNAL OF CANCER, 95, 1525-1528 [10.1038/sj.bjc.6603441].
Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa
Piazzi G;PATERINI, PAOLA;CECCARELLI, CLAUDIO;PANTALEO, MARIA ABBONDANZA;BIASCO, GUIDO
2006
Abstract
The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.File in questo prodotto:
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