Matrix metalloproteinases (MMP) 2 and 9 are enzymes known to degrade several protein components of the extracellular matrix. In humans, increased concentrations of these enzymes have been demonstrated in the cerebrospinal fluid (CSF) of subjects affected by many neurological conditions, including brain tumours; nevertheless comparative data in dogs are completely lacking. Aim of this study was to investigate these molecules in CSF of dogs diagnosed with CNS neurological diseases. Higher activity of MMP was revealed in dogs with space-occupying lesions and disk herniation in comparison to dogs with idiopathic epilepsy. Our data resulted similar to human founding, where MMPs have been recognised to play a key role on blood-brain-barrier breakdown.
Ribeiro LA, Zannoni A, Bacci ML, Forni M. (2006). Differential expression of VEGF isoforms in pig corpora lutea throughout the estrous cycle. VETERINARY RESEARCH COMMUNICATIONS, 30 (Suppl 1), 199-201 [10.1007/s11259-006-0040-x].
Differential expression of VEGF isoforms in pig corpora lutea throughout the estrous cycle.
DE ANDREA RIBEIRO, LUCIANA;ZANNONI, AUGUSTA;BACCI, MARIA LAURA;FORNI, MONICA
2006
Abstract
Matrix metalloproteinases (MMP) 2 and 9 are enzymes known to degrade several protein components of the extracellular matrix. In humans, increased concentrations of these enzymes have been demonstrated in the cerebrospinal fluid (CSF) of subjects affected by many neurological conditions, including brain tumours; nevertheless comparative data in dogs are completely lacking. Aim of this study was to investigate these molecules in CSF of dogs diagnosed with CNS neurological diseases. Higher activity of MMP was revealed in dogs with space-occupying lesions and disk herniation in comparison to dogs with idiopathic epilepsy. Our data resulted similar to human founding, where MMPs have been recognised to play a key role on blood-brain-barrier breakdown.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
