Non-cardiac determinants of NT-proBNP levels in the elderly: relevance of hematocrit and hepatic steatosis.

Background: The levels of B-type natriuretic peptide (BNP), a marker of heart failure, are higher in women and anaemic subjects, and tend to be lower in obese people. These relationships are still largely unexplained and it is unclear whether they also apply to the N-terminal portion of BNP precursor (NT-proBNP). Aims: This cross-sectional study was performed to assess general and abdominal obesity, sex and other variables as possible extra-cardiac determinants of NT-proBNP. Methods and results: A random sample of 713 subjects aged 65-74 years resident of Pianoro (Northern Italy) underwent assessment of NT-proBNP, several haemato-chemical variables, body mass index (BMI), body fat estimation (through skinfold measurement), waist circumference, intra-abdominal thickness and possible presence of hepatic steatosis (by ultrasound examination). An echocardiogram was performed in a subset of 125 subjects. In multivariable analysis NT-proBNP was inversely associated with haematocrit (r=0.22, P<0.0001) and hepatic steatosis (r=0.13, P=0.0001), while no association was found with BMI and body fat estimation. NT-proBNP was higher in women, but this relationship disappeared when haematocrit was included in the multivariable model. The associations with haematocrit and hepatic steatosis were independent from echocardiographic measurements. Conclusion: NT-proBNP is increased in subjects with low haematocrit, which explains the higher values in women. Although NT-proBNP is not affected by general adiposity, low levels of NT-proBNP are associated with hepatic steatosis.

Titolo: Non-cardiac determinants of NT-proBNP levels in the elderly: relevance of hematocrit and hepatic steatosis.
Autore/i: MUSCARI, ANTONIO; BERZIGOTTI, ANNALISA; BIANCHI, GIAMPAOLO; GIANNONI, CLAUDIA; Ligabue A.; MAGALOTTI, DONATELLA; Sbano D.; Zacchini A.; ZOLI, MARCO
Autore/i Unibo: 
MUSCARI, ANTONIO  
BERZIGOTTI, ANNALISA  
BIANCHI, GIAMPAOLO  
GIANNONI, CLAUDIA  
MAGALOTTI, DONATELLA  
ZOLI, MARCO  
mostra contributor esterni 
Anno: 2006
Rivista: 
EUROPEAN JOURNAL OF HEART FAILURE  
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/j.ejheart.2005.10.018
Abstract: Background: The levels of B-type natriuretic peptide (BNP), a marker of heart failure, are higher in women and anaemic subjects, and tend to be lower in obese people. These relationships are still largely unexplained and it is unclear whether they also apply to the N-terminal portion of BNP precursor (NT-proBNP). Aims: This cross-sectional study was performed to assess general and abdominal obesity, sex and other variables as possible extra-cardiac determinants of NT-proBNP. Methods and results: A random sample of 713 subjects aged 65-74 years resident of Pianoro (Northern Italy) underwent assessment of NT-proBNP, several haemato-chemical variables, body mass index (BMI), body fat estimation (through skinfold measurement), waist circumference, intra-abdominal thickness and possible presence of hepatic steatosis (by ultrasound examination). An echocardiogram was performed in a subset of 125 subjects. In multivariable analysis NT-proBNP was inversely associated with haematocrit (r=0.22, P<0.0001) and hepatic steatosis (r=0.13, P=0.0001), while no association was found with BMI and body fat estimation. NT-proBNP was higher in women, but this relationship disappeared when haematocrit was included in the multivariable model. The associations with haematocrit and hepatic steatosis were independent from echocardiographic measurements. Conclusion: NT-proBNP is increased in subjects with low haematocrit, which explains the higher values in women. Although NT-proBNP is not affected by general adiposity, low levels of NT-proBNP are associated with hepatic steatosis.
Data prodotto definitivo in UGOV: 2007-01-08 16:07:16
Data stato definitivo: 2020-10-19T18:54:34Z
Appare nelle tipologie:1.01 Articolo in rivista

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