The aim of this study was to evaluate the capacity of cellulose films enriched with oleic acid and polysorbate 80 to enhance the transdermal permeation of propranolol hydrochloride. Polymeric films were prepared by casting and drying aqueous solutions of hydroxypropylmethylcellulose or carboxymethylcellulose and characterized in chemical–physical properties, such as drug content, thickness, morphology and water uptake capacity. In vitro transport experiments were performed in order to evaluate the permeation enhancing ability of oleic acid and polysorbate 80. All carboxymethylcellulose films showed lower cumulative amounts of drug permeated than hydroxypropylmethylcellulose. Moreover, films containing both oleic acid and polysorbate 80 provided a greater permeation in comparison to film without permeation enhancers or only with one of these. The results obtained confirm that propranolol hydrochloride permeation can be easily modulated by varying the cellulose and enhancer type used for film preparation.

Federica Bigucci, Angela Abruzzo, Teresa Cerchiara, Maria Caterina Gallucci, Barbara Luppi (2015). Formulation of cellulose film containing permeation enhancers for prolonged delivery of propranolol hydrocloride. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 41(6), 1017-1025 [10.3109/03639045.2014.925914].

Formulation of cellulose film containing permeation enhancers for prolonged delivery of propranolol hydrocloride

BIGUCCI, FEDERICA;ABRUZZO, ANGELA;CERCHIARA, TERESA;LUPPI, BARBARA
2015

Abstract

The aim of this study was to evaluate the capacity of cellulose films enriched with oleic acid and polysorbate 80 to enhance the transdermal permeation of propranolol hydrochloride. Polymeric films were prepared by casting and drying aqueous solutions of hydroxypropylmethylcellulose or carboxymethylcellulose and characterized in chemical–physical properties, such as drug content, thickness, morphology and water uptake capacity. In vitro transport experiments were performed in order to evaluate the permeation enhancing ability of oleic acid and polysorbate 80. All carboxymethylcellulose films showed lower cumulative amounts of drug permeated than hydroxypropylmethylcellulose. Moreover, films containing both oleic acid and polysorbate 80 provided a greater permeation in comparison to film without permeation enhancers or only with one of these. The results obtained confirm that propranolol hydrochloride permeation can be easily modulated by varying the cellulose and enhancer type used for film preparation.
2015
Federica Bigucci, Angela Abruzzo, Teresa Cerchiara, Maria Caterina Gallucci, Barbara Luppi (2015). Formulation of cellulose film containing permeation enhancers for prolonged delivery of propranolol hydrocloride. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 41(6), 1017-1025 [10.3109/03639045.2014.925914].
Federica Bigucci; Angela Abruzzo; Teresa Cerchiara; Maria Caterina Gallucci; Barbara Luppi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/300313
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