Objective: to develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs. Design: molecular epidemiology study. Setting: S. Orsola-Malpighi Hospital in Bologna, Italy nurses exposed to antiblastic drugs. Participants: 50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits. Main outcome measures: urinary markers of exposure; Heat Shock Proteins (HSPs) 27, 70, 90, 110; immunological biomarkers in peripheral blood lymphocytes; apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors for IL-2 in peripheral blood lymphocytes; micronuclei: frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation of specific oncogenes (bax, bcl2, b-actin). Results: 19/50 subjects showed urinary antiblastic drugs levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups. Conclusion: this biomonitoring study doesn’t evidence any early significant effect associated to the exposure to antiblastic drugs.
Bolognesi C., Nucci MC., Colacci AM., Grilli S., Ippoliti F., Mucci N., et al. (2005). BIOMONITORING OF NURSES OCCUPATIONALLY EXPOSED TO ANTINEOPLASTIC DRUGS: THE IMEPA PROJECT. EPIDEMIOLOGIA E PREVENZIONE, 29, suppl (5-6), 91-95.
BIOMONITORING OF NURSES OCCUPATIONALLY EXPOSED TO ANTINEOPLASTIC DRUGS: THE IMEPA PROJECT
NUCCI, MARIA CONCETTA;COLACCI, ANNAMARIA;GRILLI, SANDRO;CHIOZZOTTO, DANIELA;HORN, WOLFANGO;RISI, ALESSANDRO;SILINGARDI, PAOLA;VACCARI, MONICA;VIOLANTE, FRANCESCO SAVERIO
2005
Abstract
Objective: to develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs. Design: molecular epidemiology study. Setting: S. Orsola-Malpighi Hospital in Bologna, Italy nurses exposed to antiblastic drugs. Participants: 50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits. Main outcome measures: urinary markers of exposure; Heat Shock Proteins (HSPs) 27, 70, 90, 110; immunological biomarkers in peripheral blood lymphocytes; apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors for IL-2 in peripheral blood lymphocytes; micronuclei: frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation of specific oncogenes (bax, bcl2, b-actin). Results: 19/50 subjects showed urinary antiblastic drugs levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups. Conclusion: this biomonitoring study doesn’t evidence any early significant effect associated to the exposure to antiblastic drugs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
