Background:The role of second-line chemotherapy (CT) is not established in advanced biliary tract cancer (aBTC). We investigated the outcome of aBTC patients treated with second-line CT and devised a prognostic model.Methods:Baseline clinical and laboratory data of 300 consecutive aBTC patients were collected and association with overall survival (OS) was investigated by multivariable Cox models.Results:The following parameters resulted independently associated with longer OS: Eastern Cooperative Oncology Group performance status of 0 (P<0.001; hazard ratio (HR), 0.348; 95% confidence interval (CI) 0.215-0.562), CA19.9 lower than median (P=0.013; HR, 0.574; 95% CI 0.370-0.891), progression-free survival after first-line CT ⩾6 months (P=0.027; HR, 0.633; 95% CI 0.422-0.949) and previous surgery on primary tumour (P=0.027; HR, 0.609; 95% CI 0.392-0.945). We grouped the 249 patients with complete data available into three categories according to the number of fulfilled risk factors: median OS times for good-risk (zero to one factors), intermediate-risk (two factors) and poor-risk (three to four factors) groups were 13.1, 6.6 and 3.7 months, respectively (P<0.001).Conclusions:Easily available clinical and laboratory factors predict prognosis of aBTC patients undergoing second-line CT. This model allows individual patient-risk stratification and may help in treatment decision and trial design.

Multivariate prognostic factors analysis for second-line chemotherapy in advanced biliary tract cancer / Fornaro L;Cereda S;Aprile G;Di Girolamo S;Santini D;Silvestris N;Lonardi S;Leone F;Milella M;Vivaldi C;Belli C;Bergamo F;Lutrino SE;Filippi R;Russano M;Vaccaro V;Brunetti AE;Rotella V;Falcone A;Barbera MA;Corbelli J;Fasola G;Aglietta M;Zagonel V;Reni M;Vasile E;Brandi G. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - STAMPA. - 110:(2014), pp. 2165-2169. [10.1038/bjc.2014.190]

Multivariate prognostic factors analysis for second-line chemotherapy in advanced biliary tract cancer.

DI GIROLAMO, STEFANIA;SANTINI, DONATELLA;BARBERA, MARIA AURELIA;CORBELLI, JODY;BRANDI, GIOVANNI
2014

Abstract

Background:The role of second-line chemotherapy (CT) is not established in advanced biliary tract cancer (aBTC). We investigated the outcome of aBTC patients treated with second-line CT and devised a prognostic model.Methods:Baseline clinical and laboratory data of 300 consecutive aBTC patients were collected and association with overall survival (OS) was investigated by multivariable Cox models.Results:The following parameters resulted independently associated with longer OS: Eastern Cooperative Oncology Group performance status of 0 (P<0.001; hazard ratio (HR), 0.348; 95% confidence interval (CI) 0.215-0.562), CA19.9 lower than median (P=0.013; HR, 0.574; 95% CI 0.370-0.891), progression-free survival after first-line CT ⩾6 months (P=0.027; HR, 0.633; 95% CI 0.422-0.949) and previous surgery on primary tumour (P=0.027; HR, 0.609; 95% CI 0.392-0.945). We grouped the 249 patients with complete data available into three categories according to the number of fulfilled risk factors: median OS times for good-risk (zero to one factors), intermediate-risk (two factors) and poor-risk (three to four factors) groups were 13.1, 6.6 and 3.7 months, respectively (P<0.001).Conclusions:Easily available clinical and laboratory factors predict prognosis of aBTC patients undergoing second-line CT. This model allows individual patient-risk stratification and may help in treatment decision and trial design.
2014
Multivariate prognostic factors analysis for second-line chemotherapy in advanced biliary tract cancer / Fornaro L;Cereda S;Aprile G;Di Girolamo S;Santini D;Silvestris N;Lonardi S;Leone F;Milella M;Vivaldi C;Belli C;Bergamo F;Lutrino SE;Filippi R;Russano M;Vaccaro V;Brunetti AE;Rotella V;Falcone A;Barbera MA;Corbelli J;Fasola G;Aglietta M;Zagonel V;Reni M;Vasile E;Brandi G. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - STAMPA. - 110:(2014), pp. 2165-2169. [10.1038/bjc.2014.190]
Fornaro L;Cereda S;Aprile G;Di Girolamo S;Santini D;Silvestris N;Lonardi S;Leone F;Milella M;Vivaldi C;Belli C;Bergamo F;Lutrino SE;Filippi R;Russano M;Vaccaro V;Brunetti AE;Rotella V;Falcone A;Barbera MA;Corbelli J;Fasola G;Aglietta M;Zagonel V;Reni M;Vasile E;Brandi G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/283517
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