Several studies have demonstrated the presence of actively replicating human endogenous retroviruses associated with various autoimmune disorders (Perron and Seigneurin, 1999; Portis, 2002), in particular, Sjögrens's syndrome, rheumatoid arthritis, type 1 or insulin-dependent diabetes mellitus, multiple sclerosis, systemic lupus erythematosus, and systemic sclerosis. Serum antibodies specific for human intracisternal A-type particles (HIAP), a human endogenous retrovirus recognized by monoclonal antibody against HIV-1 p24 capsid protein (Garry et al, 1990), have been detected significantly in association with primary biliary cirrhosis (Mason et al, 1998) and systemic sclerosis (La Placa et al, 2004).
Serum antibodies against human intracisternal A-type particle (HIAP) endogenous retrovirus in Alopecia areata patients: a hallmark of autoimmune disease?
LA PLACA, MICHELANGELO;VITONE, FRANCESCA;BIANCHI, TOMMASO;VINCENZI, COLOMBINA;GIBELLINI, DAVIDE;RE, MARIA CARLA;TOSTI, ANTONELLA
2004
Abstract
Several studies have demonstrated the presence of actively replicating human endogenous retroviruses associated with various autoimmune disorders (Perron and Seigneurin, 1999; Portis, 2002), in particular, Sjögrens's syndrome, rheumatoid arthritis, type 1 or insulin-dependent diabetes mellitus, multiple sclerosis, systemic lupus erythematosus, and systemic sclerosis. Serum antibodies specific for human intracisternal A-type particles (HIAP), a human endogenous retrovirus recognized by monoclonal antibody against HIV-1 p24 capsid protein (Garry et al, 1990), have been detected significantly in association with primary biliary cirrhosis (Mason et al, 1998) and systemic sclerosis (La Placa et al, 2004).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
