In recent years, increasing knowledge about in vitro cell handling and culturing has encouraged a variety of CMOS- based approaches to stimulate and detect electrical activity of biological cells. This paper outlines in a topical review the scope of cell-based biosensors and actuators for in vitro applications ranging from single-cell detection to multisite probing of complex neural tissue. Recent examples are selected to demonstrate how standard CMOS processes have been used to engineer arrays with different functionality. Index Terms—Cell-based biosensors, cell manipulation, dielec- trophoresis, extracellular recording, image sensors, in vitro, multi- electrode array (MEA), multisite recording, neurons.
JENKER M., TARTAGNI M., HIERLEMAN A., THEWES R. (2004). Cell-Based CMOS Sensor and Actuator Arrays. IEEE JOURNAL OF SOLID-STATE CIRCUITS, 39, 2431-2437 [10.1109/JSSC.2004.837082].
Cell-Based CMOS Sensor and Actuator Arrays
TARTAGNI, MARCO;
2004
Abstract
In recent years, increasing knowledge about in vitro cell handling and culturing has encouraged a variety of CMOS- based approaches to stimulate and detect electrical activity of biological cells. This paper outlines in a topical review the scope of cell-based biosensors and actuators for in vitro applications ranging from single-cell detection to multisite probing of complex neural tissue. Recent examples are selected to demonstrate how standard CMOS processes have been used to engineer arrays with different functionality. Index Terms—Cell-based biosensors, cell manipulation, dielec- trophoresis, extracellular recording, image sensors, in vitro, multi- electrode array (MEA), multisite recording, neurons.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
