In recent years, increasing knowledge about in vitro cell handling and culturing has encouraged a variety of CMOS- based approaches to stimulate and detect electrical activity of biological cells. This paper outlines in a topical review the scope of cell-based biosensors and actuators for in vitro applications ranging from single-cell detection to multisite probing of complex neural tissue. Recent examples are selected to demonstrate how standard CMOS processes have been used to engineer arrays with different functionality. Index Terms—Cell-based biosensors, cell manipulation, dielec- trophoresis, extracellular recording, image sensors, in vitro, multi- electrode array (MEA), multisite recording, neurons.

Cell-Based CMOS Sensor and Actuator Arrays

TARTAGNI, MARCO;
2004

Abstract

In recent years, increasing knowledge about in vitro cell handling and culturing has encouraged a variety of CMOS- based approaches to stimulate and detect electrical activity of biological cells. This paper outlines in a topical review the scope of cell-based biosensors and actuators for in vitro applications ranging from single-cell detection to multisite probing of complex neural tissue. Recent examples are selected to demonstrate how standard CMOS processes have been used to engineer arrays with different functionality. Index Terms—Cell-based biosensors, cell manipulation, dielec- trophoresis, extracellular recording, image sensors, in vitro, multi- electrode array (MEA), multisite recording, neurons.
2004
JENKER M.; TARTAGNI M.; HIERLEMAN A.; THEWES R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/2695
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