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EnglishDentin is a collagen-based mineralized tissue consisting of inorganic apatite crystallites embedded in an extracellular matrix. In addition to type I collagen, the dentin organic matrix contains several proteins and proteoglycans, collectively referred as non-collagenous proteins, that play fundamental roles in actively promoting, controlling and regulating fibrillogenesis, crystal growth and mineralization during dentinogenesis. Similarly to collagen fibrils, non-collagenous proteins are synthesized and secreted by odontoblasts and some of them are detectable in both predentin and mineralized dentin, others only within the dentin layer. Non-collagenous components include proteoglycans (such as chondroitin-4/6-sulphate, decorin, biglycan, lumican, fibromodulin) and several glycoproteins such as: osteocalcin, osteonectin and the SIBLINGs proteins (i.e. osteopontin, bone sialoprotein, dentin matrix protein-1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein). The first part of this review offers an overview on the nature of the above mentioned non-collagenous proteins of the dentin organic matrix and their postulated functions, since a better understanding of the biological dynamics of the extracellular macromolecules is fundamental to clarify properties and function of the human mature sound dentin.
| Titolo: | A review on nature, role and functions of dentin non-collagenous proteins. Part I: proteoglycans and glycoproteins. | |
| Autore/i: | Orsini G; Ruggeri A. Jr; MAZZONI, ANNALISA; Nato F; Mazzotti G; Putignano A; Tjäderhane L; BRESCHI, LORENZO | |
| Autore/i Unibo: | ||
| Anno: | 2012 | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1601-1546.2012.00270.x | |
| Abstract: | Dentin is a collagen-based mineralized tissue consisting of inorganic apatite crystallites embedded in an extracellular matrix. In addition to type I collagen, the dentin organic matrix contains several proteins and proteoglycans, collectively referred as non-collagenous proteins, that play fundamental roles in actively promoting, controlling and regulating fibrillogenesis, crystal growth and mineralization during dentinogenesis. Similarly to collagen fibrils, non-collagenous proteins are synthesized and secreted by odontoblasts and some of them are detectable in both predentin and mineralized dentin, others only within the dentin layer. Non-collagenous components include proteoglycans (such as chondroitin-4/6-sulphate, decorin, biglycan, lumican, fibromodulin) and several glycoproteins such as: osteocalcin, osteonectin and the SIBLINGs proteins (i.e. osteopontin, bone sialoprotein, dentin matrix protein-1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein). The first part of this review offers an overview on the nature of the above mentioned non-collagenous proteins of the dentin organic matrix and their postulated functions, since a better understanding of the biological dynamics of the extracellular macromolecules is fundamental to clarify properties and function of the human mature sound dentin. | |
| Data prodotto definitivo in UGOV: | 2014-12-15 23:54:16 | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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