A highly stereoselective organocatalytic α-alkylation of 2-arylacetaldehydes with a commercially available carbenium tetrafluoroborate is described. The stereoselective alkylation was carried out in acetonitrile/water, under air in the presence of a commercially available imidazolidinone (MacMillan's catalyst). Key intermediates for the synthesis of bisabolanes were obtained through a simple chemistry. In particular a direct, enantioselective and facile synthesis of (R)-(-)-curcumene is described

A Straightforward Organocatalytic Alkylation of 2-Arylacetaldehydes: An Approach towards Bisabolanes / Andrea Gualandi; Pietro Canestrari; Enrico Emer; Pier Giorgio Cozzi. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4169. - STAMPA. - 356:2-3(2014), pp. 528-536. [10.1002/adsc.201300250]

A Straightforward Organocatalytic Alkylation of 2-Arylacetaldehydes: An Approach towards Bisabolanes

GUALANDI, ANDREA;COZZI, PIER GIORGIO
2014

Abstract

A highly stereoselective organocatalytic α-alkylation of 2-arylacetaldehydes with a commercially available carbenium tetrafluoroborate is described. The stereoselective alkylation was carried out in acetonitrile/water, under air in the presence of a commercially available imidazolidinone (MacMillan's catalyst). Key intermediates for the synthesis of bisabolanes were obtained through a simple chemistry. In particular a direct, enantioselective and facile synthesis of (R)-(-)-curcumene is described
2014
A Straightforward Organocatalytic Alkylation of 2-Arylacetaldehydes: An Approach towards Bisabolanes / Andrea Gualandi; Pietro Canestrari; Enrico Emer; Pier Giorgio Cozzi. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4169. - STAMPA. - 356:2-3(2014), pp. 528-536. [10.1002/adsc.201300250]
Andrea Gualandi; Pietro Canestrari; Enrico Emer; Pier Giorgio Cozzi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/261312
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