Aim of the study was to evaluate the influence of familiarity on th prevalence of gallstone disease in Italy. Families of 79 subjects with gallstones and of 79 subjects without gallstones were investigated for the presence of gallstones by ultrasonography. Prevalence of gallstones was significantly higher in the 201 first-degree relatives of subjects without gallstones; in particular prevalence was significantly higher in mothers, fathers, and sisters of index cases than that in the respective family members of index controls. The study confirms that familiarity plays a very important role in the pathogenesis of gallstones.
Prevalence of gallstone disease in first-degree relatives of patients with cholelithiasis
RODA, ENRICO;FESTI, DAVIDE;
2005
Abstract
Aim of the study was to evaluate the influence of familiarity on th prevalence of gallstone disease in Italy. Families of 79 subjects with gallstones and of 79 subjects without gallstones were investigated for the presence of gallstones by ultrasonography. Prevalence of gallstones was significantly higher in the 201 first-degree relatives of subjects without gallstones; in particular prevalence was significantly higher in mothers, fathers, and sisters of index cases than that in the respective family members of index controls. The study confirms that familiarity plays a very important role in the pathogenesis of gallstones.File in questo prodotto:
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