Proline and pyrrolidine derivatives (Hayashi– Jørgensen catalysts) are considered “work horses” in organocatalysis. This report describes a new effective ferrocenyl pyrrolidine catalyst that is able to perform well in benchmark organocatalytic reactions (see figure). The ferrocene moiety controls the conformational space and a simple alkyl group effectively covers a face of the derived enamine. This new framework can find applications in organocatalysis, and in general, in new ligand design
Petruzziello D., Stenta M., Mazzanti A., Cozzi P.G. (2013). A Rational Approach Towards a New Ferrocenyl Pyrrolidine for Stereoselective Enamine Catalysis. CHEMISTRY-A EUROPEAN JOURNAL, 19(24), 7696-7700 [10.1002/chem.201300959].
A Rational Approach Towards a New Ferrocenyl Pyrrolidine for Stereoselective Enamine Catalysis
MAZZANTI, ANDREA;COZZI, PIER GIORGIO
2013
Abstract
Proline and pyrrolidine derivatives (Hayashi– Jørgensen catalysts) are considered “work horses” in organocatalysis. This report describes a new effective ferrocenyl pyrrolidine catalyst that is able to perform well in benchmark organocatalytic reactions (see figure). The ferrocene moiety controls the conformational space and a simple alkyl group effectively covers a face of the derived enamine. This new framework can find applications in organocatalysis, and in general, in new ligand designI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
