Background: Intra-abdominal infections are one of the most common infections encountered by a general surgeon. However, despite this prevalence, standardized guidelines outlining the proper use of antibiotic therapy are poorly defined due to a lack of clinical trials investigating the ideal duration of antibiotic treatment. The aim of this study is to compare the efficacy and safety of a three-day treatment regimen of Ampicillin-Sulbactam to that of a three-day regimen of Ertapenem in patients with localized peritonitis ranging from mild to moderate severity. Methods: This study is a prospective, multi-center, randomized investigation performed in the Department of General, Emergency, and Transplant Surgery of St. Orsola-Malpighi University Hospital in Bologna, Italy. Discrete data were analyzed using the Chi-squared and Fisher exact tests. Differences between the two study groups were considered statistically significant for p-values less than 0.05. Results: 71 patients were treated with Ertapenem and 71 patients were treated with Ampicillin-Sulbactam. The two groups were comparable in terms of age and gender as well as the site of abdominal infection. Post-operative infection was identified in 12 patients: 10 with wound infections and 2 with intra-abdominal infections. In the Ertapenem group, 69 of the 71 patients (97%) were treated successfully, while the therapy failed in 2 cases (3%). Therapy failures were more frequent in the Unasyn group, amounting to 10 of 71 cases (p = 0.03). Conclusion: According to these preliminary findings, the authors conclude that a three-day Ertapenem treatment regimen is the most effective antibiotic therapy for patients with localized intra-abdominal infections ranging from mild to moderate severity.

Fausto Catena, Carlo Vallicelli, Luca Ansaloni, Massimo Sartelli, Salomone Di Saverio, Riccardo Schiavina, et al. (2013). T.E.A. Study: three-day ertapenem versus three-day Ampicillin-Sulbactam. BMC GASTROENTEROLOGY, 13, 1-6 [10.1186/1471-230X-13-76].

T.E.A. Study: three-day ertapenem versus three-day Ampicillin-Sulbactam

CATENA, FAUSTO;VALLICELLI, CARLO;DI SAVERIO, SALOMONE;SCHIAVINA, RICCARDO;PASQUALINI, EDDI;AMADUZZI, ANNALISA;COCCOLINI, FEDERICO;CUCCHI, MICHELE;PINNA, ANTONIO DANIELE
2013

Abstract

Background: Intra-abdominal infections are one of the most common infections encountered by a general surgeon. However, despite this prevalence, standardized guidelines outlining the proper use of antibiotic therapy are poorly defined due to a lack of clinical trials investigating the ideal duration of antibiotic treatment. The aim of this study is to compare the efficacy and safety of a three-day treatment regimen of Ampicillin-Sulbactam to that of a three-day regimen of Ertapenem in patients with localized peritonitis ranging from mild to moderate severity. Methods: This study is a prospective, multi-center, randomized investigation performed in the Department of General, Emergency, and Transplant Surgery of St. Orsola-Malpighi University Hospital in Bologna, Italy. Discrete data were analyzed using the Chi-squared and Fisher exact tests. Differences between the two study groups were considered statistically significant for p-values less than 0.05. Results: 71 patients were treated with Ertapenem and 71 patients were treated with Ampicillin-Sulbactam. The two groups were comparable in terms of age and gender as well as the site of abdominal infection. Post-operative infection was identified in 12 patients: 10 with wound infections and 2 with intra-abdominal infections. In the Ertapenem group, 69 of the 71 patients (97%) were treated successfully, while the therapy failed in 2 cases (3%). Therapy failures were more frequent in the Unasyn group, amounting to 10 of 71 cases (p = 0.03). Conclusion: According to these preliminary findings, the authors conclude that a three-day Ertapenem treatment regimen is the most effective antibiotic therapy for patients with localized intra-abdominal infections ranging from mild to moderate severity.
2013
Fausto Catena, Carlo Vallicelli, Luca Ansaloni, Massimo Sartelli, Salomone Di Saverio, Riccardo Schiavina, et al. (2013). T.E.A. Study: three-day ertapenem versus three-day Ampicillin-Sulbactam. BMC GASTROENTEROLOGY, 13, 1-6 [10.1186/1471-230X-13-76].
Fausto Catena; Carlo Vallicelli; Luca Ansaloni; Massimo Sartelli; Salomone Di Saverio; Riccardo Schiavina; Eddi Pasqualini; Annalisa Amaduzzi; Federic...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/254336
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