3,6-Disubstituted-4,5-di[(S)-1-phenylethylamino]-1,7-octadienes with different configurations at the carbon stereocenters, were protected as dihydrochlorides or cyclic phosphorous diamides and then converted to (1R,2R)-3,6-disubstituted-1,2-diaminocyclohexanes through ruthenium-catalyzed ring closing metathesis and subsequent hydrogenolysis-hydrogenation steps.
Carla Boga, Claudio Fiorelli, Diego Savoia (2006). Stereoselective synthesis of 3,6-disubstituted-1,2-diaminocyclohexanes through ring closing metathesis of 4,5-diamino-1,7-octadienes derivatives. SYNTHESIS, 2, 285-292 [10.1055/s-2005-918515].
Stereoselective synthesis of 3,6-disubstituted-1,2-diaminocyclohexanes through ring closing metathesis of 4,5-diamino-1,7-octadienes derivatives
BOGA, CARLA;FIORELLI, CLAUDIO;SAVOIA, DIEGO
2006
Abstract
3,6-Disubstituted-4,5-di[(S)-1-phenylethylamino]-1,7-octadienes with different configurations at the carbon stereocenters, were protected as dihydrochlorides or cyclic phosphorous diamides and then converted to (1R,2R)-3,6-disubstituted-1,2-diaminocyclohexanes through ruthenium-catalyzed ring closing metathesis and subsequent hydrogenolysis-hydrogenation steps.File in questo prodotto:
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